Results 291 to 300 of about 120,334 (323)

CREB Binding Protein—Coactivator Complexes

2000
CREB binding protein (CBP) and p300 are structurally related coactivator proteins that are required for the function of several classes of regulated transcription factors (Fig. 1). CBP and p300 function in part by serving as molecular scaffolds that direct the assembly of multiprotein coactivator complexes (Fig. 2).
Riki Kurokawa, Christopher K. Glass
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CREB-binding protein (CREBBP) and preeclampsia: a new promising target gene

Molecular Biology Reports, 2021
Preeclampsia (PE) is a major complication of pregnancy and remains a leading cause of neonatal and maternal mortality worldwide. Several studies have revealed that the incidence of preeclampsia is high in mothers who carried a fetus with Rubinstein-Taybi Syndrome due to the mutation in CREBBP. We aimed to compare the expression level of the CERBBP gene
Hossein Sadeghi, Sahra Esmkhani, Reihaneh Pirjani, Mona Amin-Beidokhti, Milad Gholami, Ghasem Azizi Tabesh, Mohammad Reza Ghasemi, Latif Gachkar, Reza Mirfakhraie   +8 more
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Distribution of CREB-binding protein immunoreactivity in the adult rat brain

Brain Research, 1999
We demonstrate the expression of the co-activator CREB-binding protein (CBP) in the nuclei of a large number of neurons and glial structures in the rat brain and spinal cord. Immunoblotting of nuclear extracts revealed a single band at 265 kDa, the size of CBP.
H, Strömberg, S P, Svensson, O, Hermanson   +2 more
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The calcium-responsive transactivator recruits CREB binding protein to nuclear bodies

Neuroscience Letters, 2004
The calcium-responsive transactivator (CREST) is required for the normal development of neuronal dendritic trees. Here we report that CREST is localized to sub-nuclear structures in the rat neuroendocrine pheochromocytoma PC12 cells. A yellow fluorescence protein-CREST fusion protein was expressed in HEK 293 and PC12 cells and the recombinant protein ...
Anuradha, Pradhan, Yuechueng, Liu
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Investigation of the interaction between CREB-binding protein and STAT4/STAT6

Molecular Biology Reports, 2010
Coactivator CBP (CREB-binding protein) has been implicated in the regulation of transcription for all signal transducer and activator of transcription factors (STATs); however, the mechanism remains unclear. Using yeast two-hybrid screening and immunoprecipitation techniques, we investigated the direct interaction of CBP with STAT4 and STAT6.
Mingxiang, Zhang, Zhou, Fu, Daiyin, Tian, Enmei, Liu, Jihong, Dai, Lijia, Wang   +5 more
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Implications of transcriptional coactivator CREB binding protein complexes in rheumatoid arthritis

Modern Rheumatology, 2004
Transcriptional coactivators have crucial roles in eukaryotic transcription. It has been suggested that one of the coactivators, cAMP response element binding protein (CREB) binding protein (CBP), regulates gene expression with a number of transcription factors via two mechanisms.
Toshihiro, Nakajima, Satoko, Aratani, Minako, Nakazawa, Takuji, Hirose, Hidetoshi, Fujita, Kusuki, Nishioka   +5 more
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CREB-binding protein silencing inhibits thrombin-induced endothelial progenitor cells angiogenesis

Molecular Biology Reports, 2011
Endothelial progenitor cells (EPCs) are known to promote neovascularization in ischemic diseases. Recent evidence from our group suggested that CREB-binding protein (CBP) plays an important role in thrombin-induced EPCs migration. However, whether CBP could regulate EPCs angiogenic properties is unknown.
Hong, Jiang, Si-si, Chen, Jian, Yang, Jing, Chen, Bo, He, Li-hua, Zhu, Lang, Wang   +6 more
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CREB-binding protein and p300: molecular integrators of hematopoietic transcription

Blood, 2000
Differentiation of pluripotent hematopoietic stem cells into mature circulating blood cells is coordinated by a complex series of transcriptional events. During the last decade, numerous transcription factors have been identified whose expression is highly lineage-restricted within the ...
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CREB-binding proteins (CBP) as a transcriptional coactivator of GATA-2

Science in China Series C: Life Sciences, 2008
The GATA family consists of six members, GATA 1-6. In this study, we focused on GATA-2, which is expressed predominantly in hematopoietic progenitor cells and plays the key role in keeping these cells in the undifferentiated status. CREB-binding proteins (CBP) are essential transcriptional coactivators for a large number of regulated DNA-binding ...
HuiJie, Jiang, LinDe, Liu, ShuDe, Yang, Takahashi, Tomomi, Nakano, Toru   +4 more
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Functional interaction between Smad, CREB binding protein, and p68 RNA helicase

Biochemical and Biophysical Research Communications, 2004
The transforming growth factors beta control a diversity of biological processes including cellular proliferation, differentiation, apoptosis, and extracellular matrix production, and are critical effectors of embryonic patterning and development, including that of the orofacial region.
Dennis R, Warner, Vasker, Bhattacherjee, Xiaolong, Yin, Saurabh, Singh, Partha, Mukhopadhyay, M Michele, Pisano, Robert M, Greene   +6 more
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