Results 281 to 290 of about 120,334 (323)

Shikonin improves intestinal barrier function through modulation of GPX4 expression in intestinal epithelial cells. [PDF]

Int J Immunopathol Pharmacol
Yang F, Liang P, Guo H, Yan W, Wang G, Tang X, Liang Z.   +6 more
europepmc   +1 more source

The expanding landscape of the glucagon signaling network: mechanisms and outcomes.

Endocrinology
Foollee A, Wu Y, Rusu PM, Rose AJ.
europepmc   +1 more source

Effect of ALA on preventing diabetic peripheral neuropathy in rats through mitochondrial axonal transport. [PDF]

PLoS One
Tian J, An J, Song L, Zhang W, Chen D, Zhang T, Ben Y.   +6 more
europepmc   +1 more source

CaMKII as a Multimodal Signalling Hub in Neural Connectivity and Vulnerability. [PDF]

Mol Neurobiol
Olliff S, Sundaramoorthy V.
europepmc   +1 more source

Roflumilast Elicits Therapeutic and Neuroprotective Effects in 3-Nitropropionic Acid-Induced Huntington's Disease-Like Neurodegeneration in Rats by Mitigating NLRP3 Inflammasome-Mediated Pyroptosis, Ferroptosis, and Glial Activation. [PDF]

Neurochem Res
Taha M, Salah D, Abdou K, Senousy MA.
europepmc   +1 more source

MYCN inhibits TrkC-mediated differentiation in neuroblastoma cells via disruption of the PKA signalling pathway. [PDF]

Cell Death Discov
Maher S, Roe A, Wynne K, Zhernovkov V, Halasz M.   +4 more
europepmc   +1 more source

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Differential Use of CREB Binding Protein-Coactivator Complexes

Science, 1998
CREB binding protein (CBP) functions as an essential coactivator of transcription factors that are inhibited by the adenovirus early gene product E1A. Transcriptional activation by the signal transducer and activator of transcription–1 (STAT1) protein requires the C/H3 domain in CBP, which is the primary target of E1A inhibition. Here it was found that
R, Kurokawa, D, Kalafus, M H, Ogliastro, C, Kioussi, L, Xu, J, Torchia, M G, Rosenfeld, C K, Glass   +7 more
openaire   +4 more sources

Phosphorylated CREB binds specifically to the nuclear protein CBP

Nature, 1993
Cyclic AMP-regulated gene expression frequently involves a DNA element known as the cAMP-regulated enhancer (CRE). Many transcription factors bind to this element, including the protein CREB, which is activated as a result of phosphorylation by protein kinase A.
J C, Chrivia, R P, Kwok, N, Lamb, M, Hagiwara, M R, Montminy, R H, Goodman   +5 more
openaire   +4 more sources

Insulin regulation of hepatic gluconeogenesis through phosphorylation of CREB-binding protein

Nature Medicine, 2004
Hepatic gluconeogenesis is essential for maintenance of normal blood glucose concentrations and is regulated by opposing stimulatory (cyclic adenosine monophosphate, cAMP) and inhibitory (insulin) signaling pathways. The cAMP signaling pathway leads to phosphorylation of cAMP response element-binding (CREB) protein, resulting in recruitment of the ...
Xiao Yan, Zhou, Nobuyuki, Shibusawa, Karuna, Naik, Delia, Porras, Karla, Temple, Hesheng, Ou, Kelly, Kaihara, Michael W, Roe, Matthew J, Brady, Fredric E, Wondisford   +9 more
openaire   +4 more sources