Results 51 to 60 of about 120,334 (323)

Inhibition of cAMP responsive element binding protein in striatal neurons enhances approach and avoidance responses towards morphine- and morphine withdrawal-related cues

Frontiers in Behavioral Neuroscience, 2009
To investigate the role of cAMP resposive element binding protein (CREB)-dependent gene expression in morphine induced behaviors, we examined bitransgenic mice expressing a dominant and strong inhibitor of the CREB family of transcription factors, A-CREB,
Carles Sanchis-Segura, Dragana Jancic, Maria Jimenez-Minchan, Angel Barco   +3 more
doaj   +1 more source

Xuebijing Protects Against Septic Acute Liver Injury Based on Regulation of GSK-3β Pathway

Frontiers in Pharmacology, 2021
Xuebijing (XBJ), the only drug approved for the sepsis and multiple organ dysfunction, and its protective effects against acute liver injury (ALI) and its mechanism. The aim of this study was to evaluate the protective effect of XBJ on cecal ligation and
Liping Cao, Liping Cao, Zhenghong Li, Yi Ren, Mengmeng Wang, Zhizhou Yang, Wei Zhang, Xiaoqin Han, Mengya Yao, Zhaorui Sun, Shinan Nie   +10 more
doaj   +1 more source

Gem-induced cytoskeleton remodeling increases cellular migration of HTLV-1-infected cells, formation of infected-to-target T-cell conjugates and viral transmission [PDF]

, 2013
Efficient HTLV-1 viral transmission occurs through cell-to-cell contacts. The Tax viral transcriptional activator protein facilitates this process. Using a comparative transcriptomic analysis, we recently identified a series of genes up-regulated in HTLV-
Afonso, PV, Brady, JN, Cachat, A, Chevalier, SA, Gessain, A, Mahieux, R, Pise-Masison, CA, Turpin, J   +7 more
core   +1 more source

CREB-binding Protein/p300 Co-activation of Crystallin Gene Expression [PDF]

Journal of Biological Chemistry, 2002
Although some of the transcription factors that are required for expression of crystallins during lens development have been identified, the molecular interactions that contribute to enhanced crystallin expression are not yet well defined. In this study, we designed experiments to test whether the co-activators CREB-binding protein (CBP) and/or p300 ...
Chen, Qin, Dowhan, Dennis H., Liang, Dongcai C., Moore, David D. D., Overbeek, Paul A.   +4 more
openaire   +3 more sources

The dynamic properties of a nuclear coactivator binding domain are evolutionarily conserved

Communications Biology, 2022
Reconstruction of an ancient nuclear coactivator binding domain (NCBD) of CREB-binding protein from a bilaterian animal ancestor living 600 million years ago reveals conserved dynamic properties in human NCBD.
Elin Karlsson, Frieda A. Sorgenfrei, Eva Andersson, Jakob Dogan, Per Jemth, Celestine N. Chi   +5 more
doaj   +1 more source

A zinc transporter gene required for development of the nervous system. [PDF]

, 2013
The essentiality of zinc for normal brain development is well established. It has been suggested that primary and secondary zinc deficiencies can contribute to the occurrence of numerous human birth defects, including many involving the central nervous ...
Chowanadisai, Winyoo, Graham, David M, Keen, Carl L, Messerli, Mark A, Rucker, Robert B   +4 more
core   +1 more source

Prothymosin α interacts with the CREB‐binding protein and potentiates transcription [PDF]

EMBO reports, 2002
Prothymosin α (ProTα) is a histone H1‐binding protein localized in sites of active transcription in the nucleus. We report here that ProTα physically interacts with the CREB‐binding protein (CBP), which is a versatile transcription co‐activator. Confocal laser scanning microscopy reveals that ProTα partially colocalizes with CBP in discrete subnuclear ...
Karetsou, Z., Kretsovali, A., Murphy, C., Tsolas, O., Papamarcaki, T.   +4 more
openaire   +3 more sources

Increasing levels of wild-type CREB up-regulates several activity-regulated inhibitor of death (AID) genes and promotes neuronal survival

BMC Neuroscience, 2012
Background CREB (cAMP-response element binding protein) is the prototypical signal-regulated transcription factor. In neurons, it is the target of the synaptic activity-induced nuclear calcium-calcium/calmodulin dependent protein kinase (CaMK) IV ...
Tan Yan-Wei, Zhang Sheng-Jia, Hoffmann Tina, Bading Hilmar   +3 more
doaj   +1 more source

p38α MAPK regulates proliferation and differentiation of osteoclast progenitors and bone remodeling in an aging-dependent manner. [PDF]

, 2017
Bone mass is determined by the balance between bone formation, carried out by mesenchymal stem cell-derived osteoblasts, and bone resorption, carried out by monocyte-derived osteoclasts.
Ao, Junping, Cong, Qian, Jia, Hao, Li, Baojie, Li, Ping, Liu, Huijuan, Qiu, Shoutao, Wang, Yibin, Yeh, James, Zhang, Zhen-Lin   +9 more
core   +1 more source

Complex regulation of CREB-binding protein by homeodomain-interacting protein kinase 2 [PDF]

Cellular Signalling, 2015
CREB-binding protein (CBP) and p300 are transcriptional coactivators involved in numerous biological processes that affect cell growth, transformation, differentiation, and development. In this study, we provide evidence of the involvement of homeodomain-interacting protein kinase 2 (HIPK2) in the regulation of CBP activity.
Kovács, Krisztián A., Steinmann, Myriam, Halfon, Olivier, Magistretti, Pierre J., Cardinaux, Jean-René   +4 more
openaire   +4 more sources