Results 41 to 50 of about 120,334 (323)

Acetylation of β-Catenin by CREB-binding Protein (CBP) [PDF]

Journal of Biological Chemistry, 2002
Acetylation controls the activity of numerous proteins involved in regulating gene transcription as well as many other cellular processes. In this report we show that the CREB-binding protein (CBP) acetyltransferase acetylates beta-catenin protein in vivo.
Daniel, Wolf, Marianna, Rodova, Eric A, Miska, James P, Calvet, Tony, Kouzarides   +4 more
openaire   +2 more sources

PABPN1 functions as a downstream gene of CREB to inhibit the proliferation of preadipocytes [PDF]

Animal Bioscience
Objective This study was conducted to reveal the role of nuclear poly(A) binding protein 1 (PABPN1) in the proliferation of preadipocytes, and to reveal the relationship between PABPN1 and cAMP response element (CRE)-binding protein (CREB) in the ...
Xiao-Han Zhang, Jia-Xin Li, Xiao-Xu Wu, Qian Zhang, Ming Tian, Si-Qi Yang, Di Liu, Xiu-Qin Yang   +7 more
doaj   +1 more source

Learning and nicotine interact to increase CREB phosphorylation at the jnk1 promoter in the hippocampus. [PDF]

PLoS ONE, 2012
Nicotine is known to enhance long-term hippocampus dependent learning and memory in both rodents and humans via its activity at nicotinic acetylcholinergic receptors (nAChRs).
Justin W Kenney, Rachel L Poole, Michael D Adoff, Sheree F Logue, Thomas J Gould   +4 more
doaj   +1 more source

Extinction of gene expression in somatic cell hybrids. a reflection of important regulatory mechanisms? [PDF]

, 1993
Extinction in somatic cell hybrids is a multifactorial process that leads to loss of cell-type-specific gene expression. The underlying mechanisms are thought to mirror, at least in part, the repertoire of regulatory mechanisms controlling mammalian cell
Boshart, Michael, Nitsch, Doris, Schütz, Günther   +2 more
core   +1 more source

CREB-binding protein/p300 are transcriptional coactivators of p65 [PDF]

Proceedings of the National Academy of Sciences, 1997
CBP (CREB-binding protein) and p300 are versatile coactivators that link transcriptional activators to the basal transcriptional apparatus. In the present study, we identify CBP and p300 as coactivators of the nuclear factor-κB (NF-κB) component p65 (RelA).
M E, Gerritsen, A J, Williams, A S, Neish, S, Moore, Y, Shi, T, Collins   +5 more
openaire   +2 more sources

Regulation of podocyte survival and endoplasmic reticulum stress by fatty acids and its modification by Stearoyl-CoA desaturases and cyclic AMP [PDF]

, 2011
Podocyte apoptosis is a hallmark in the development and progression of diabetic nephropathy (DN). Several factors of the diabetic milieu are known to induce podocyte apoptosis. Currently, the role of free fatty acids (FFAs) for podocytopathy and podocyte
Sieber, Jonas
core   +1 more source

Fatty acid binding protein 5 promotes the proliferation, migration, and invasion of hepatocellular carcinoma cells by degradation of Krüppel-like factor 9 mediated by miR-889-5p via cAMP-response element binding protein

Cancer Biology & Therapy, 2022
Mounting evidence has demonstrated that fatty acid binding protein 5 (FABP5) is commonly upregulated in many human malignancies. However, the mechanisms explaining the involvement of FABP5 in hepatocellular carcinoma (HCC) remain unclear.
Yanping Tang, Kezhi Li, Bangli Hu, Zhengmin Cai, Jilin Li, Hao Tao, Ji Cao   +6 more
doaj   +1 more source

Structural Diversity in p160/CREB-binding Protein Coactivator Complexes [PDF]

Journal of Biological Chemistry, 2006
Ligand-induced transcription by nuclear receptors involves the recruitment of p160 coactivators such as steroid receptor coactivator 1 (SRC1), in complex with histone acetyltransferases such as CREB-binding protein (CBP) and p300. Here we describe the solution structure of a complex formed by the SRC1 interaction domain (SID) of CBP and the activation ...
Waters, L, Yue, B, Veverka, V, Renshaw, P, Bramham, J, Matsuda, S, Frenkiel, T, Kelly, G, Muskett, F, Carr, M, Heery, DM   +10 more
openaire   +3 more sources

Extinction of tyrosine aminotransferase gene activity in somatic cell hybrids involves modification and loss of several essential transcription factors [PDF]

, 1993
Extinction is defined as the loss of cell type-specific gene expression that occurs in somatic cell hybrids derived by fusion of cells with dissimilar phenotypes.
Boshart, Michael, Nitsch, Doris, Schütz, Günther   +2 more
core   +1 more source

Conserved and distinct modes of CREB/ATF transcription factor regulation by PP2A/B56gamma and genotoxic stress. [PDF]

PLoS ONE, 2010
Activating transcription factor 1 (ATF1) and the closely related proteins CREB (cyclic AMP resonse element binding protein) and CREM (cyclic AMP response element modulator) constitute a subfamily of bZIP transcription factors that play critical roles in ...
Naval P Shanware, Lihong Zhan, John A Hutchinson, Sang Hwa Kim, Leah M Williams, Randal S Tibbetts   +5 more
doaj   +1 more source