Results 121 to 130 of about 91,942 (288)

Adenosine—A Regulator of Human Testicular Peritubular Cells

Andrology, EarlyView.
ABSTRACT Background Extracellular purines, in particular ATP and adenosine, are regulators of physiological and pathophysiological processes throughout the human body. Roles in the human testis are emerging and include actions on peritubular cells, which form the wall of seminiferous tubules.
Lina Scholz, Annika Liebich, Youli Stepanov, Jan B. Stöckl, Mirko Peitzsch, Michaela Schneider, Julia Schneider, Nicole Kreitmair, Matthias Trottmann, Frank‐Michael Köhn, Jovica Ninkovic, Thomas Fröhlich, Artur Mayerhofer   +12 more
wiley   +1 more source

Activation of cyclic AMP response element-binding protein (CREB) in aggressive periodontal disease

, 2009
OBJECTIVES: To report a novel observation of neutrophil signal transduction abnormalities in patients with localized aggressive periodontitis (LAP) that are associated with an enhanced phosphorylation of the nuclear signal transduction protein cyclic AMP
Buchmann, Rainer, Sculean, Anton, Roessler, Ralf   +2 more
core  

Ang II increases CREB and NF-κB activity in an AT1R and CREB-dependent manner.

, 2013
CATH.a neurons were transfected with CREB and NF-κB reporter constructs, consisting of a mixture of CREB and NF-κB - responsive luciferase constructs and a constitutively expressing Renilla construct. (A) NF-κB relative luciferase activity was quantified
Amit K. Mitra (482450), Karla K. V. Haack (482449), Irving H. Zucker (482451)   +2 more
core   +1 more source

SIRT1 in Neurodegenerative Diseases: Molecular Mechanisms, Disease Relevance, and Therapeutic Potential [PDF]

FASEB J
SIRT1, an NAD+‐dependent deacetylase, supports cognitive resilience by coordinating neuroprotection, synaptic plasticity, autophagy–lysosomal proteostasis, and mitochondrial energy homeostasis. Reduced or dysregulated SIRT1 is associated with protein aggregation, neuroinflammation, mitochondrial dysfunction, synaptic loss, and cognitive decline in ...
Duan J, Liu J, Meng Q, Liu J, Yang S, Zhou F, Cao J.   +6 more
europepmc   +2 more sources

Olfactory proteomics reveals the capacity of the HDAC1 inhibitor pyroxamide to halt the α‐synuclein preformed fibrils‐induced damage in nasal epithelial, microglial and dopaminergic neuronal cell lines

Brain Pathology, EarlyView.
Omics‐driven drug repositioning reveals pyroxamide as a neuroprotective HDAC1 inhibitor in Parkinson's disease models. Abstract Parkinson's disease (PD) is the second most common neurodegenerative disorder mainly characterized by the degeneration of dopaminergic neurons originating in the substantia nigra (SN) pars compacta and projecting to other ...
Paz Cartas‐Cejudo, Marina De Miguel, Leire Extramiana, Mercedes Lachén‐Montes, Silvia Romero‐Murillo, Djordje Gveric, Joaquín Fernández‐Irigoyen, Enrique Santamaría   +7 more
wiley   +1 more source

Effects of TAN-67 and Naltrindole on striatal expression of p-CREB/CREB at 24 hrs after MCAO.

, 2013
A, Representative fluorescent micrographs of striatal p-CREB (green) and CREB (red) positive cells in sham and the core of MCAO groups. Bar = 20 µm. B, Representative Western blot images of p-CREB/CREB expression in different groups.
Xuesong Tian (429357), Gencheng Wu (429360), Jingchun Guo (429358), Min Zhu (168912), Ying Xia (222301), Minwei Li (429359)   +5 more
core   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Icariside II in Neurological Disorders: Mechanistic Insights Into Alzheimer's Disease, Cerebral Ischemia and Parkinson's Disease. [PDF]

J Biochem Mol Toxicol
The graphical abstract represents the underlying neuroprotective potential of ICS II against Alzheimer's disease, Cerebral ischemia and Parkinson disease. ICS II downregulates ROS production, inflammation, mitochondrial dysfunction and apoptosis along with regulating their key signalling pathways.
Solanki A, Sharma K, Jain J, Singh NK, Krishnamurthy PT.   +4 more
europepmc   +2 more sources

DPPC regulates COX-2 expression in monocytes via phosphorylation of CREB

, 2008
The major phospholipid in pulmonary surfactant dipalmitoyl phosphatidylcholine (DPPC) has been shown to modulate inflammatory responses. Using human monocytes, this study demonstrates that DPPC significantly increased PGE2 (P < 0.05) production by 2.5 ...
M.K. Ahluwalia, Tonks, Alex, Tonks, Amanda J., A.W. Thomas, Jackson, S. K., Jones, K. P., Tonks, Amanda Jayne, R.H.K. Morris, S.K. Jackson, Thomas, A.W, A. Tonks, Thomas, A. W., Jackson, Simon K., Morris, R. H. K., K.P. Jones, Morris, R. H.K., A.J. Tonks, Ahluwalia, M. K.   +17 more
core   +1 more source

Impact of incretin analogues on lipid and lipoprotein metabolism in obesity and diabetes

British Journal of Pharmacology, EarlyView.
Abstract Incretin‐based therapies have gained momentum as a key strategy for reducing cardiovascular risk in individuals with obesity and/or type 2 diabetes (T2D). It remains unclear whether the cardiovascular benefits reflect a direct reduction in atherogenic lipoproteins—namely, low‐density lipoproteins (LDL), very low‐density lipoproteins (VLDL) and
Andrea Baragetti, Giuseppe Danilo Norata
wiley   +1 more source