Results 111 to 120 of about 87,086 (298)
iNew Medicine, EarlyView.Therapeutic mechanism, clinical efficacy and future directions for nerandomilast in pulmonary fibrosis. ABSTRACT The recent Phase III FIBRONEER trials establish nerandomilast, a novel oral phosphodiesterase 4B (PDE4B) inhibitor, as an effective therapy for idiopathic and progressive pulmonary fibrosis. By elevating cyclic adenosine monophosphate (cAMP),
Qianwen Bai +4 more
wiley +1 more source
Acupuncture Activates ERK-CREB Pathway in Rats Exposed to Chronic Unpredictable Mild Stress
, 2013 Extracellular signal-regulated kinase (ERK)-cAMP response element binding protein (CREB) signal pathway has been implicated in the pathogenesis of depression.
Tu, Ya +5 more
core
Interdisciplinary Medicine, EarlyView.The developing bone was identified as an M2a‐like macrophage driven immune microenvironment with multidimensional developmental signatures. hME‐ApoEVs were successfully fabricated via stimulating the M2a‐like developing microenvironment in vitro and confirmed its recapitulation of developmental features.
Xiaoran Yu +11 more
wiley +1 more source
Interdisciplinary Medicine, EarlyView.This review explores how Fusobacterium nucleatum extracellular vesicles drive local oral diseases and distal pathologies via sophisticated cross‐compartment cross talk. It highlights the transformative potential of these “tiny carriers” as next‐generation molecular intermediaries for advanced health monitoring and innovative bio‐interventions by ...
Rongyang Ma +6 more
wiley +1 more source
Ang II increases CREB and NF-κB activity in an AT1R and CREB-dependent manner.
, 2013 CATH.a neurons were transfected with CREB and NF-κB reporter constructs, consisting of a mixture of CREB and NF-κB - responsive luciferase constructs and a constitutively expressing Renilla construct. (A) NF-κB relative luciferase activity was quantified
Amit K. Mitra (482450) +2 more
core +1 more source
Interdisciplinary Medicine, EarlyView.Integrated multi‐omics reveals that CD36‐mediated lipid overload in PBMCs drives T cell exhaustion via sub‐lethal ferroptotic stress and AKT suppression. This systemic metabolic signature serves as a robust predictor of immunotherapy response in HCC, suggesting that modulating lipid metabolism can rescue immune fitness.
Ying Zhu +6 more
wiley +1 more source
Activation of cyclic AMP response element-binding protein (CREB) in aggressive periodontal disease
, 2009 OBJECTIVES: To report a novel observation of neutrophil signal transduction abnormalities in patients with localized aggressive periodontitis (LAP) that are associated with an enhanced phosphorylation of the nuclear signal transduction protein cyclic AMP
Buchmann, Rainer +2 more
core
Effects of TAN-67 and Naltrindole on striatal expression of p-CREB/CREB at 24 hrs after MCAO.
, 2013 A, Representative fluorescent micrographs of striatal p-CREB (green) and CREB (red) positive cells in sham and the core of MCAO groups. Bar = 20 µm. B, Representative Western blot images of p-CREB/CREB expression in different groups.
Xuesong Tian (429357) +5 more
core +1 more source
Journal of Applied Toxicology, EarlyView.ABSTRACT Accumulating evidence suggests that paternal environmental factors have epigenetic effects on sperm and influence offspring. Neonicotinoid pesticides (NNs), which are widely used around the world, are known to affect offspring phenotypes through maternal exposure in mice, but the effect of the paternal exposure remains unknown.
Makiko Ito +11 more
wiley +1 more source
DPPC regulates COX-2 expression in monocytes via phosphorylation of CREB
, 2008 The major phospholipid in pulmonary surfactant dipalmitoyl phosphatidylcholine (DPPC) has been shown to modulate inflammatory responses. Using human monocytes, this study demonstrates that DPPC significantly increased PGE2 (P < 0.05) production by 2.5 ...
M.K. Ahluwalia +17 more
core +1 more source