Results 101 to 110 of about 87,086 (298)
iLABMED, EarlyView.This article reviews the pivotal role of post‐translational modifications of proteins in the development and progression of hematologic malignancies, and explores their clinical translation potential as novel biomarkers and therapeutic targets. ABSTRACT Post‐translational modifications (PTMs) of proteins have emerged as critical regulators in the ...
Yuxuan Han +6 more
wiley +1 more source
Molecular Metabolism, 2014 Objective: Glucagon-like peptide-1 (GLP-1) plays a major role in pancreatic β-cell function and survival by increasing cytoplasmic cAMP levels, which are thought to affect transcription through activation of the basic leucine zipper (bZIP) transcription ...
Soona Shin +5 more
doaj +1 more source
BMC Neuroscience, 2012 Background CREB (cAMP-response element binding protein) is the prototypical signal-regulated transcription factor. In neurons, it is the target of the synaptic activity-induced nuclear calcium-calcium/calmodulin dependent protein kinase (CaMK) IV ...
Tan Yan-Wei +3 more
doaj +1 more source
TORCs: Transducers of regulated CREB activity
, 2003 The CAMP responsive factor CREB stimulates gene expression, following its phosphorylation at Ser133, via recruitment of the coactivator CBP. In certain cell types, CREB also functions as a constitutive activator, although the underlying mechanisms are ...
J. B. Hogenesch +6 more
core +1 more source
Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials
iNew Medicine, EarlyView.ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong +5 more
wiley +1 more source
Targeted mutation of the CREB gene: compensation within the CREB/ATF family of transcription factors
, 1994 The cAMP response element binding protein (CREB) has been implicated as a key regulator in the transcriptional control of many genes. To assess the functional importance of CREB in vivo and its role in development, we used gene targeting to generate mice
Aguzzi, A. +7 more
core +2 more sources
Diversification on Small Farms: An Empirical Investigation of Panel Data for 2001–10
Lahore Journal of EconomicsPakistan’s agricultural sector has experienced restructuring over the last decade, from changes in land markets to the move toward nonagricultural labor markets.
Sadia Hussain, Farah Said
doaj
The CaMK4/CREB/IRS-2 cascade stimulates proliferation and inhibits apoptosis of β-cells.
PLoS ONE, 2012 Progressive reduction in β-cell mass is responsible for the development of type 2 diabetes mellitus, and alteration in insulin receptor substrate 2 (IRS-2) abundance plays a critical role in this process.
Bo Liu +4 more
doaj +1 more source
Molecular Mechanisms of Memory: Identification and Modeling
, 2009 (i) Understanding how memory is formed is an essential question in Neuroscience and is necessary to treat memory disorders, like Alzheimer’s disease.
MARASCO, ADDOLORATA
core
CREB protein in the mouse lung.
, 2013 (A) Representative images of western blots of CREB protein expression (α and Δ isoforms) under normoxic and hypoxic conditions in wild-type and CREBαΔ mice. (B) Representative images of western blots of total CREB protein expression (α, β, and Δ isoforms)
Katherine Howell (494610) +8 more
core +1 more source