Results 81 to 90 of about 139,153 (288)

Enterohemorrhagic Escherichia coli infection inhibits colonic thiamin pyrophosphate uptake via transcriptional mechanism. [PDF]

, 2019
Colonocytes possess a specific carrier-mediated uptake process for the microbiota-generated thiamin (vitamin B1) pyrophosphate (TPP) that involves the TPP transporter (TPPT; product of the SLC44A4 gene).
Anandam, Kasin Yadunandam, Sabui, Subrata, Said, Hamid M, Subramanian, Sreya, Thompson, Morgan M   +4 more
core   +1 more source

Imaging CREB Activation in Living Cells [PDF]

Journal of Biological Chemistry, 2010
The Ca(2+)- and cAMP-responsive element-binding protein (CREB) and the related ATF-1 and CREM are stimulus-inducible transcription factors that link certain forms of cellular activity to changes in gene expression. They are attributed to complex integrative activation characteristics, but current biochemical technology does not allow dynamic imaging of
Friedrich, M., Aramuni, G., Mank, M., Mackinnon, J., Griesbeck, O.   +4 more
openaire   +3 more sources

Fosl2 Regulates FSH‐Dependent Follicle Maturation Through Feedback Amplification of FSH/FSHR Signaling

Advanced Science, EarlyView.
This study identifies a FOSL2‐driven positive feedback loop that amplifies FSH/FSHR signaling. During FSH‐dependent follicle maturation, FSH induces Fosl2 expression via the cAMP‐PKA‐CREB cascade. FOSL2 in turn binds the promoters of Fshr and estrogen‐biosynthesis genes to enhance their transcription, thereby increasing Fshr mRNA level and amplifying ...
Hongru Shi, Chaoli Chen, Zaohong Ran, Jianning Liao, Zian Wu, Xiaodong Wang, Yongheng Zhao, Wenkai Ke, Bowen Tan, Yun Liu, Youqiang Su, Wei Ren, Xiang Li, Changjiu He   +13 more
wiley   +1 more source

Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair

Advanced Science, EarlyView.
We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing, Yang Yang, Zichen Hong, Chunhui Tian, Huiyu Chu, Susanne Clara Prokop, Hongwei Cai, Mingxia Gu, Jason Tchieu, Ken Mackie, Feng Guo   +10 more
wiley   +1 more source

Pentylenetetrazol and Morphine Interaction in a State-dependent Memory Model: Role of CREB Signaling

Basic and Clinical Neuroscience, 2020
Introduction: State-dependent (STD) memory is a process, in which the learned information can be optimally retrieved only when the subject is in the state similar to the encoding phase. This phenomenon has been widely studied with morphine.
Marziyeh Tavassoli, Abolfazl Ardjmand
doaj  

Evaluación de la Función Neuromuscular del Antebrazo durante contracciones isométricas mediante Electromiografía de Superficie Multicanal

Revista Iberoamericana de Automática e Informática Industrial RIAI, 2011
Resumen: Desarrollo de un protocolo experimental con ejercicios de flexión isométrica de los dedos y muñeca asociado a lesiones de esfuerzo repetitivo, y validación de la electromiografía de superficie multicanal como técnica no invasiva en la ...
Mónica Rojas-Martínez, Michelle García, Joan Francesc Alonso, Jesús Marín, Miguel Ángel Mañanas   +4 more
doaj   +1 more source

CREB Can Get You Depressed [PDF]

Neuron, 1999
Many neuronal systems exhibit both a protein synthesis–independent early phase of synaptic plasticity and a distinct late phase of synaptic plasticity, which lasts many hours or days and requires new protein synthesis and gene transcription. Similarly, memory has both a short-term component that is independent of protein synthesis and a long-term ...
openaire   +2 more sources

Natural Resistance to Ovarian Hyperstimulation Syndrome in Estrildid Finches Reveals Macrophage GPR183 as a Potential Therapeutic Target

Advanced Science, EarlyView.
Ovarian macrophage depletion reverses OHSS resistance in estrildid finches and exacerbates OHSS symptoms in rats. Activating macrophage GPR183 alleviates OHSS by reducing pro‐inflammatory factors, increasing immunomodulatory molecules, remodeling CD44/SDC4‐mediated communication, and restoring immune homeostasis.
Xiaofei Yan, Yongjie Huang, Jiabao Yang, Su Ma, Songsong Liu, Xuan Huang, Juergen Brosius, Huaping Zheng, Bing Yao, Li Chen, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

Cyclic mechanical strain causes cAMP-response element binding protein activation by different pathways in cardiac fibroblasts

Heart International, 2010
The transcription factor cAMP-response element binding protein (CREB) mediates the mechanical strain-induced gene expression in the heart. This study investigated which signaling pathways are involved in the strain-induced CREB activation using cultured ...
Britta Husse, Gerrit Isenberg
doaj   +1 more source

Extinction of tyrosine aminotransferase gene activity in somatic cell hybrids involves modification and loss of several essential transcription factors [PDF]

, 1993
Extinction is defined as the loss of cell type-specific gene expression that occurs in somatic cell hybrids derived by fusion of cells with dissimilar phenotypes.
Boshart, Michael, Nitsch, Doris, Schütz, Günther   +2 more
core   +1 more source