Results 131 to 140 of about 87,086 (298)

Minimal residual disease in diffuse large B‐cell lymphoma after first‐line therapy: Defining the continuum from metabolic remission to molecular clearance

British Journal of Haematology, EarlyView.
Summary Response assessment in diffuse large B‐cell lymphoma (DLBCL) has traditionally relied on anatomical and metabolic imaging, with fluorodeoxyglucose positron emission tomography (FDG‐PET)–defined complete metabolic remission representing the principal end‐point of first‐line therapy. However, growing evidence indicates that metabolic control does
Santino Caserta, Enrica Antonia Martino, Ernesto Vigna, Antonella Bruzzese, Mamdouh Skafi, Nicola Amodio, Eugenio Lucia, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Maria Eugenia Alvaro, Fortunato Morabito, Massimo Gentile   +12 more
wiley   +1 more source

The non-canonical CRE is associated with CREB occupancy and CREB-responsiveness of endogenous genes.

, 2013
(A and B) Histograms depict spatial accumulation of mouse hippocampal CREB ChIP-Seq peaks relative to all genomic occurrences of the canonical CRE (TGACG) and the non-canonical CRE (TGGCG).
Carl Pelz (418820), Adam Lesiak (418819), Katelin F. Hansen (359358), Monika Davare (418823), Gary A. Wayman (359360), Talley J. Lambert (358201), Mingyan Zhu (418822), Suzanne M. Appleyard (418824), Soren Impey (359361), Karl Obrietan (359362), Hideaki Ando (418821)   +10 more
core   +1 more source

Down-regulation of serotonergic genes expression in the raphe nuclei of midbrain under chronic social defeat stress in male mice

, 2011
Background: There is ample experimental evidence supporting the hypothesis that the brain serotonergic system is involved in the control of chronic social defeat stress (CSDS), depression and anxiety.
Ul’yana A. Boyarskikh, Natalya P. Bondar, Natalia N. Kudryavtseva, Maxim L. Filipenko   +3 more
core  

CREB activates proteasomal degradation of DSCR1/RCAN1

, 2008
The cyclic AMP response element-binding protein (CREB) is involved in the development and function of the nervous system. Here, we find that CREB decreases the protein level of Regulator of Calcineurin Activity 1 (RCAN1/DSCR1/MCIP1), which is ...
Chung, Kwang Chul, Seo, Su Ryeon, Kwang Chul Chung, Su Ryeon Seo   +3 more
core   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

cAMP response element binding protein (CREB) overexpression CREB has been described as critical for leukemia progression.

, 2007
CREB has been described as critical for leukemia progress. We investigated CREB expression in ALL and AML pediatric patients.
RICOTTI E, PIGAZZI, MARTINA, FAGGIAN D, ARICO M, GERMANO G, BASSO, GIUSEPPE   +5 more
core  

CREB engages C/EBPδ to initiate leukemogenesis

, 2016
cAMP response element binding protein (CREB) is frequently overexpressed in acute myeloid leukemia (AML) and acts as a proto-oncogene; however, it is still debated whether such overactivation alone is able to induce leukemia as its pathogenetic ...
TREGNAGO, CLAUDIA, BRESOLIN, SILVIA, Germano G, Manara E, PIGAZZI, MARTINA, Borga C, BASSO, GIUSEPPE, Aveic S, Zampini M2, BISIO, VALERIA   +9 more
core   +1 more source

Dual pharmacological targeting of coactivator‐associated arginine methyltransferase 1 (CARM1) and salt inducible kinase (SIK) drives ketogenesis in both hepatocytes and mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Ketone bodies are liver‐derived circulating energy metabolites that positively impact most hallmarks of ageing. Ketone bodies increase during calorie restriction and fasting, two of the more widely perceived methods to increase health span.
Tábata Bergonci, Troels Kjær Rosenbæk, Samuel J. Windross, Ulrik B. Keiding, Estéfano Pinilla, Katrine P. Stuckert, Jakob Hansen, Camilla B. Nielsen, Jemila Peter Gomes, Lucy R. Davies, Johan Palmfeldt, Volker Loeschcke, Charlotte U. Andersen, Ulf Simonsen, Thomas B. Poulsen, Mogens Johannsen   +15 more
wiley   +1 more source

CREB co-localizes with intracytoplasmic CTF aggregates and quantity of CREB is decreased in cultured cell model.

, 2013
(A) In non-transfected PC12 cells, CREB and p-CREB-immunofluorescence labeling is strong in the nucleus, while the cytoplasm shows only weak and diffuse immunofluorescence. (B) In PC12 cells over-expressing rCTF-Q28-NES, the cytoplasmic CTF aggregates co-
Yoshinobu Eishi (245152), Hitoshi Takahashi (144276), Yusuke Niimi (386776), Kinya Ishikawa (386783), Fuminori Tsuruta (386780), Mitsunori Yamada (235697), Kokoro Ozaki (386777), Nozomu Sato (386775), Takeo Kato (113464), Masato Obayashi (386773), Makoto Takahashi (386772), Kaoru Mogushi (386778), Yasen Mahmut (386779), Osamu Mori (386782), Hiroshi Tanaka (3087), Taro Ishiguro (386774), Ricardo Dolmetsch (386781), Hidehiro Mizusawa (275410)   +17 more
core   +1 more source

Impact of incretin analogues on lipid and lipoprotein metabolism in obesity and diabetes

British Journal of Pharmacology, EarlyView.
Abstract Incretin‐based therapies have gained momentum as a key strategy for reducing cardiovascular risk in individuals with obesity and/or type 2 diabetes (T2D). It remains unclear whether the cardiovascular benefits reflect a direct reduction in atherogenic lipoproteins—namely, low‐density lipoproteins (LDL), very low‐density lipoproteins (VLDL) and
Andrea Baragetti, Giuseppe Danilo Norata
wiley   +1 more source