A randomized, controlled field study to assess the efficacy and safety of lotilaner flavored chewable tablets (Credelio™ CAT) in eliminating fleas in client-owned cats in the USA [PDF]
Parasites & Vectors, 2021 Background Studies show that the novel isoxazoline, lotilaner (Credelio™ CAT; Elanco Animal Health), which is administered orally to cats, provides rapid and sustained flea kill for least 1 month following administration with a wide safety margin.
Kimberly Chappell +4 more
doaj +5 more sources
The novel isoxazoline ectoparasiticide lotilaner (Credelio™): a non-competitive antagonist specific to invertebrates γ-aminobutyric acid-gated chloride channels (GABACls) [PDF]
Parasites & Vectors, 2017 Background The isoxazolines are a novel class of parasiticides that are potent inhibitors of γ-aminobutyric acid (GABA)-gated chloride channels (GABACls) and, to a lesser extent, of inhibitory glutamate-gated chloride channels (GluCls).
Lucien Rufener +3 more
doaj +4 more sources
Field study to investigate the effectiveness and safety of a novel orally administered combination drug product containing milbemycin oxime and lotilaner (Credelio® Plus) for the prevention of heartworm disease (Dirofilaria immitis) in client-owned dogs in the USA [PDF]
Parasites & Vectors, 2021 Background Dirofilaria immitis, a globally distributed filarial parasite of dogs, is known to cause serious or fatal cardiopulmonary disease. Client-owned dogs were enrolled in a clinical field study in the USA to evaluate the clinical effectiveness and ...
Lisa M. Young +4 more
doaj +5 more sources
Safety of oral afoxolaner formulated with or without milbemycin oxime in homozygous MDR1-deficient collie dogs. [PDF]
J Vet Pharmacol Ther, 2022 Abstract Afoxolaner, an insecticide and acaricide compound of the isoxazoline class, is available for dogs as an oral ectoparasiticide medicine (NexGard®) and as an oral endectoparasiticide medicine in combination with milbemycin oxime (MO), a macrocyclic lactone (NexGard® Spectra).
Drag M, Tielemans E, Mitchell E.
europepmc +2 more sources
Survey of canine use and safety of isoxazoline parasiticides. [PDF]
Vet Med Sci, 2020 A veterinarian and pet owner survey (Project Jake) examined the use and safety of isoxazoline parasiticides given to dogs during August 1‐31, 2018 from 2751 survey responses. When any preventive treatment was given, AE were reported for 66.6% of respondents, with no apparent AE noted for 36.1%.
Palmieri V +7 more
europepmc +2 more sources
Efficacy of lotilaner against myiasis caused by Cochliomyia hominivorax (Diptera: Calliphoridae) in naturally infested dogs [PDF]
Parasites & Vectors, 2023 Background The New World screwworm fly, Cochliomyia hominivorax, is widely distributed across South America. This parasitic insect is a significant cause of primary myiasis in animals, including dogs.
Tássia Lopes do Vale +9 more
doaj +2 more sources
A randomized, controlled field study to assess the efficacy and safety of lotilaner (Credelio™) in controlling ticks in client-owned cats in Europe [PDF]
Parasites & Vectors, 2018 Background There is a continuing need for novel approaches to tick infestations treatment and control in cats. Lotilaner, an isoxazoline with rapid onset of action, has proven its efficacy against ticks in laboratory studies.
Daniela Cavalleri +3 more
doaj +6 more sources
The intravenous and oral pharmacokinetics of lotilaner in dogs
Parasites & Vectors, 2017 Background Lotilaner is a new oral ectoparasiticide from the isoxazoline class developed for the treatment of flea and tick infestations in dogs. It is formulated as pure S-enantiomer in flavoured chewable tablets (Credelio™).
Céline E. Toutain +2 more
doaj +2 more sources
Menrath ulcers in cats: four cases (2014-2023). [PDF]
J Small Anim PractObjectives To report the clinical presentation, treatment and outcomes of four cats diagnosed with Menrath ulcers causing significant oral haemorrhage. Materials and Methods For all cats, data on signalment, history, physical examination, treatment and outcomes were collected by reviewing medical records.
Whybrow K, Hernon T, Pilot M.
europepmc +2 more sources
A randomized, controlled field study to assess the efficacy and safety of lotilaner (Credelio™) in controlling fleas in client-owned cats in Europe [PDF]
Parasites & Vectors, 2018 Background Lotilaner is a new isoxazoline developed as an oral ectoparasiticide for cats and dogs. Its safety, rapid killing onset of action and sustained speed of fleas and ticks kill for a minimum of one month after administration, were demonstrated in
Daniela Cavalleri +3 more
doaj +2 more sources