Results 51 to 60 of about 29,556 (312)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Creep-fatigue life assessment of cruciform weldments using the linear matching method
, 2013 This paper presents a creep-fatigue life assessment of a cruciform weldment made of the steel AISI type 316N(L) and subjected to reversed bending and cyclic dwells at 550C using the Linear Matching Method (LMM) and considering different weld zones.
Chen, Haofeng, Gorash, Yevgen
core +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Anisotropic creep model for soft soils
, 2008 In this paper a new anisotropic model for time-dependent behaviour of soft soils is presented. The formulation is based on a previously developed isotropic creep model, assuming rotated Modified Cam Clay ellipses as contours of volumetric creep strain ...
Leoni, Martino +10 more
core +1 more source
High-temperature creep of single-crystal nickel-based superalloy : microstructural changes and effects of thermal cycling [PDF]
, 2011 Creep tests were performed on MC2 single crystal superalloy at 950°C/200 MPa and 1150°C/80 MPa under isothermal and thermal cycling conditions with a tensile axis along the [0 0 1] direction. It was found that the thermal cycles strongly affect the creep
Eric Andrieu +6 more
core +1 more source
Creep model of roadway surrounding rock considering hardening effect and damage effect.
PLoS ONEThe influence of confining pressure on creep characteristics was analyzed by carrying out creep tests of rocks under different confining pressures. A new creep model of roadway surrounding rock considering the combined influence of hardening effect and ...
Hongmiao Lv
doaj +1 more source
Experimental and modeling study of salt rock creep behavior under loading and unloading history
工程科学学报The influence of loading and unloading history on creep deformation suggests that the cyclic stress environment in underground engineering (e.g.: excavation, backfilling, and unloading) can significantly impact the long-term stability of salt rock.
Fan YANG +4 more
doaj +1 more source
Geofluids, 2021 The hazards induced by stratified rock mass creep are still one of the major problems that threaten the safety of underground engineering. This paper takes safe construction of underground roadway in Urumqi mining area as the research background. In this
Yiran Yang +4 more
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source