Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Effect of temperature on aging and time-temperature superposition in nonergodic Laponite suspensions
, 2009 We have studied the effect of temperature on aging dynamics of laponite suspensions by carrying out the rheological oscillatory and creep experiments.
Baghdadi +22 more
core +1 more source
Application of time–stress superposition to viscoelastic behavior of polyamide 6,6 fiber and its “true” elastic modulus [PDF]
, 2017 The viscoelastic behavior of semi-crystalline polyamide 6,6 fiber is exploited in viscoelastically prestressed polymeric matrix composites. To understand better the underlying prestress mechanisms, strain–time performance of the fiber material is ...
Babatope +46 more
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Study on the Creep Behaviors of Interactive Marine-Terrestrial Deposit Soils
Advances in Civil Engineering, 2019 The interactive marine-terrestrial (IMT) deposit soils were formed in the complex depositional environment; their mechanical properties are different from the other deposits.
Zhen Yan +3 more
doaj +1 more source
Viscous and Viscoelastic Behavior of 1,3,5-tri-alpha-naphthyl Benzene [PDF]
Torsional creep and creep recovery behavior of organic ...
Magill, J. H., Plazek, D. J.
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Procedures for characterizing an alloy and predicting cyclic life with the total strain version of Strainrange Partitioning [PDF]
Procedures are presented for characterizing an alloy and predicting cyclic life for isothermal and thermomechanical fatigue conditions by using the total strain version of strainrange partitioning (TS-SRP). Numerical examples are given.
Halford, Gary R., Saltsman, James F.
core +2 more sources
Becker and Lomnitz rheological models: a comparison
, 2012 The viscoelastic material functions for the Becker and the Lomnitz rheological models, sometimes employed to describe the transient flow of rocks, are studied and compared.
Mainardi, Francesco, Spada, Giorgio
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source