Results 81 to 90 of about 146,033 (308)
Creep Damage Evolution of Marble From Acoustic Emission and the Damage Threshold
Frontiers in Earth Science, 2020 For the underground engineering, time-dependent behavior (i.e., creep) of rocks is one of the main reasons for instability of surrounding rock in great stress conditions.
Xueying Liu +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
A study on the combined effects of creep and environment-induced damage on aluminum alloy 2219
AIP AdvancesAluminum alloys have over the years grown both in stature and in strength so as to be a prime of “preferred” candidate for use in a spectrum of applications in the industries spanning aerospace and automotive.
Shengli Lv +4 more
doaj +1 more source
Effects of misalignment on mechanical behavior of metals in creep [PDF]
Creep tests were conducted by means of a closed loop servocontrolled materials test system. The strain history prior to creep is carefully monitored. Tests were performed for aluminum alloy 6061-O at 150 C and were monitored by a PDP 11/04 minicomputer ...
Wu, H. C.
core +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Creep and Creep-rupture Behavior of 2124-T851 Aluminum Alloy
High Temperature Materials and Processes, 2013 AbstractHigh temperature creep and useful creep life behavior of Al-Cu-Mg (2124-T851 aluminum) alloy was investigated by conducting constant stress uniaxial tensile creep tests at different temperatures (473–563 K) and at stresses ranging from 80 to 200 MPa.
Jiang Yu-Qiang +4 more
openaire +2 more sources
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Atomic-scale Simulation Study of Creep Behavior in Nanocrystalline Mo
Yuanzineng kexue jishuMolybdenum (Mo) alloys are widely employed in high-temperature environments, such as advanced nuclear systems, due to their excellent properties, including high melting point and thermal conductivity. However, Mo alloys suffer from poor ductility at room
NI Weixuan, JIA Lixia, DOU Yankun, HE Xinfu, CAO Jinli, WANG Dongjie, YANG Wen
doaj +1 more source
Determination of biaxial creep strength of T-111 tantalum alloy Semiannual report, Mar. 8 - Sep. 8, 1967 [PDF]
Creep behavior of T-111 alloy tubing under biaxial stress and stress effects on corrosion behavior of T-111 alloy with ...
Engel, L. B., Jr.
core +1 more source