Results 91 to 100 of about 146,033 (308)

Modelling of the behaviour of a welded joint subjected to reverse bending moment at high temperature [PDF]

, 2007
The paper is concerned with the modeling of the behaviour of welds when subjected to severe thermal and mechanical loads where the maximum temperature during dwell periods lies in the creep range.
Chen, Haofeng, Ponter, Alan R.S.
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Creep Properties of Walikukun (Schouthenia ovata) Timber Beams

Civil Engineering Dimension, 2016
This study presents an evaluation of creep constants of Walikukun (Schoutheniaovata) timber beams when rheological model of four solid elements, which is obtained byassembling Kelvin and Maxwell bodies in parallel configuration, was adopted.
Ali Awaludin, Ngudiyono Ngudiyono, Achmad Basuki   +2 more
doaj  

A creep model for ultra-deep salt rock considering thermal-mechanical damage under triaxial stress conditions

Journal of Rock Mechanics and Geotechnical Engineering
To investigate the specific creep behavior of ultra-deep buried salt during oil and gas exploitation, a set of triaxial creep experiments was conducted at elevated temperatures with constant axial pressure and unloading confining pressure conditions ...
Chao Liang, Jianfeng Liu, Jianxiong Yang, Huining Xu, Zhaowei Chen, Lina Ran   +5 more
doaj   +1 more source

Creep strength of niobium alloys, Nb-1%Zr and PWC-11 [PDF]

A study is being conducted at NASA Lewis Research Center to determine the feasibility of using a carbide particle strengthened Nb-1 percent Zr base alloy to meet the anticipated temperature and creep resistance requirements of proposed near term space ...
Titran, Robert H.
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Anisotropic time-dependent behaviors of shale under direct shearing and associated empirical creep models

Journal of Rock Mechanics and Geotechnical Engineering
Understanding the anisotropic creep behaviors of shale under direct shearing is a challenging issue. In this context, we conducted shear-creep and steady-creep tests on shale with five bedding orientations (i.e.
Yachen Xie, Michael Z. Hou, Hejuan Liu, Cunbao Li   +3 more
doaj   +1 more source

Creep deformation and creep-rupture behavior of Cr-Mo-V steel forgings.

ISIJ International, 1990
In order to investigate creep deformation and the fracture mechanism of Cr-Mo-V steel, creep tests up to 104 h were carried out in a temperature range of 550-675°C. Metallographic observations were also conducted on the fractured specimens.The results obtained are summarized as follows:(1) Stress dependence of steady-state strain rate changes at a ...
Yoshikuni KADOYA, Toru GOTO
openaire   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Free volume and nonlinear viscoelasticity in supercrystalline nanocomposites: A nanoindentation driven modelling analysis

Materials & Design
Supercrystalline nanocomposites (SCNCs) are a new class of hybrid materials consisting of organically functionalized nanoparticles that are arranged into periodic architectures, featuring multi-functional properties.
Cong Yan, Eric Hirschmann, Marc G.D. Geers, Diletta Giuntini   +3 more
doaj   +1 more source