Results 101 to 110 of about 29,556 (312)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Indentation Creep Behavior in Ce-Based Bulk Metallic Glasses at Room Temperature

, 2005
The room temperature creep behaviors of Ce-based bulk metallic glasses were examined by the use of nanoindentation. The creep rate and creep rate sensitivity of Ce-based BMGs were derived from indentation creep curves.
王育人, 邢东梅, 张凌晨, 李维火, 魏炳忱, Wei, BC (reprint author), Chinese Acad Sci, Inst Mech, Natl Micrograv Lab, Beijing 100080, Peoples R China., 张泰华   +6 more
core   +1 more source

Free volume and nonlinear viscoelasticity in supercrystalline nanocomposites: A nanoindentation driven modelling analysis

Materials & Design
Supercrystalline nanocomposites (SCNCs) are a new class of hybrid materials consisting of organically functionalized nanoparticles that are arranged into periodic architectures, featuring multi-functional properties.
Cong Yan, Eric Hirschmann, Marc G.D. Geers, Diletta Giuntini   +3 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Multiscale modeling of upper mantle plasticity: From single-crystal rheology to multiphase aggregate deformation [PDF]

, 2014
We report a first application of an improved second-order (SO) viscoplastic self-consistent model for multiphase aggregates, applied to an olivine + diopside aggregate as analogue for a dry upper mantle peridotite deformed at 10 15 s 1 shear strain rate ...
CORDIER, Patrick, CASTELNAU, Olivier, RATERON, Paul, MERKEL, Sébastien, RATERRON, Paul, BOLLINGER, Caroline, DETREZ, Fabrice   +6 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Kinetic Simulation of the Logarithmic Creep of Cement

, 2018
Many amorphous materials display a logarithmic creep behavior, driven by the rare occurrence of complex, hardly detectable, microscopic, structural rearrangements.
Masoero, Enrico, Ulm, Franz-Josef, Manzano, H., Del Gado, E., Yip, Sidney, Pellenq, Roland Jm   +5 more
core   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

The development of advanced creep constitutive equations for high chromium steel P91 at low stress range

, 2013
Diffusion dominates the creep deformation at low stress range for high chromium steel P91. Brittle creep fracture is caused by cavity nucleation, growth and coalescence of cavities and large precipitates (Laves phase and M23C6) at grain boundary under ...
Xu, Qiang, Lou, Zhongyu, An, Lili, Lu, Zhongyu   +3 more
core  

Avaliação do tempo e condição de armazenagem na fluência em resinas compostas [PDF]

, 2015
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Odontologia, Florianópolis, 2015.Objetivo: Avaliar o comportamento viscoelástico (creep) de resinas compostas dentais sob teste de ...
Savi, Camila Gonçalves
core