Results 111 to 120 of about 146,033 (308)

On numerical integration and computer implementation of viscoplastic models [PDF]

Due to the stringent design requirement for aerospace or nuclear structural components, considerable research interests have been generated on the development of constitutive models for representing the inelastic behavior of metals at elevated ...
Chang, J. P., Chang, T. Y., Thompson, R. L.   +2 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Creep behavior of Ti-6Al-4V from 450°C to 600°C [PDF]

, 2014
We present in this paper the creep behavior of Ti-6Al-4V from 450°C to 600°C under applied stress from 100 MPa to 500 MPa. Creep behavior is studied analyzing creep damage after tests and calculating stress exponent (n) and activation energy (Q ...
Badea, Lavina, Ruau, Jacques, Surand, Martin, Viguier, Bernard   +3 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Creep recovery and stress relaxation tests of 6061-0 aluminum [PDF]

The investigation of creep recovery and stress relaxation in aluminum using a closed loop servo-hydraulic test system is described. The practicality of a computer controlled test system for constant plastic strain rate tension tests is demonstrated.
Wu, H. C., Yao, J. C.
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Tensile and creep rupture behavior of P/M processed Nb-base alloy, WC-3009 [PDF]

Due to its high strength at temperatures up to 1600 K, fabrication of niobium base alloy WC-3009 (Nb30Hf9W) by traditional methods is difficult. Powder metallurgy (P/M) processing offers an attractive fabrication alternative for this high strength alloy.
Hebsur, Mohan G., Titran, Robert H.
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Modeling the viscoplastic behavior of Inconel 718 at 1200 F [PDF]

A large number of tests, including tensile, creep, fatigue, and creep-fatigue were performed to characterize the mechanical properties of Inconel 718 (a nickel based superalloy) at 1200 F, the operating temperature for turbine blades.
Abdel-Kader, M. S., Eftis, J., Jones, D. L.   +2 more
core   +1 more source

Model B4 : multi-decade creep and shrinkage prediction of traditional and modern concretes [PDF]

, 2014
To improve the sustainability of concrete infrastructure, engineers face the challenge of incorporating new concrete materials while pushing the expected design life beyond 100 years.
Bazant, Z. P., Hubler, M. H., Wan-Wendner, Roman   +2 more
core   +1 more source