Results 121 to 130 of about 21,077 (297)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Creep characteristics of sandstone during freezing/thawing process

Shuiwen dizhi gongcheng dizhi
The rock mass in cold regions is always subjected to the load and freeze-thaw. If the impact of long-term freeze-thaw mechanical behavior on sandstone mass is neglected, it would lead to significant hazards to the construction and safe operation of ...
Yongjun SONG, Jinghui CAO, Keyan CHENG, Huimin YANG, Ran BI, Kun ZHANG   +5 more
doaj   +1 more source

Influência do teor do elemento índio nas propriedades termo-mecânicas de ligas para interconexão de componentes eletrônicos [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Ciência e Engenharia de Materiais.Este trabalho insere-se no âmbito da confiabilidade de interconexões eletrônicas.
Boareto, José Carlos
core  

Uniaxial Compression Creep Relaxation and Grading of Coal Samples via Tests on the Progressive Failure Characteristics

, 2019
An RMT-150B electrohydraulic servo testing system was used to perform uniaxial compression and uniaxial grading relaxation (creep) tests. The deformation, strength, and failure characteristics of the progressive failure process of coal samples under ...
Changsheng Song, Chengdong Su, Cheng Wang, Zuqiang Xiong, Xiaolei Wang, Yu Hao   +5 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Nonlinear damage creep model of concrete considering the influence of temperature and its parameter variation law analysis.

PLoS ONE
In order to study the creep characteristics of concrete under different temperatures, the uniaxial creep test of concrete is carried out. On this basis, the nonlinear creep model of concrete is established by using the fractal order derivative theory ...
Lu Wang
doaj   +1 more source

Study on the triaxial creep and acoustic emission characteristics of surrounding rock in high-stress caverns under different initial damage levels

Frontiers in Earth Science
To investigate the creep behavior of deep hard rock under varying initial damage conditions, brittle dolomite specimens were subjected to different pre-peak strengths under a confining pressure of 30 MPa to induce distinct initial damage levels ...
Qingtao Peng, Qingtao Peng, Kegang Li, Kegang Li, Ji Shi, Ji Shi, Mingliang Li, Mingliang Li, Qingci Qin, Qingci Qin   +9 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source