Results 101 to 110 of about 144,828 (306)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Improved method for cladding the inside of metal tubes [PDF]

, 1970
Creep characteristics of molybdenum at high temperature and stress are utilized to compress tungsten foil liner against inner surface of tantalum alloy cylinder to form bond at interface.
Maag, W. L., Mattson, W. F.
core   +1 more source

Strong-Pinning Effects in Low-Temperature Creep: Charge-Density Waves in TaS_3

, 1996
Nonlinear conduction in the quasi-one dimensional conductor o-TaS_3 has been studied in the low-temperature region down to 30 mK. It was found that at temperatures below a few Kelvins the current-voltage (I-V) characteristics consist of several branches.
A. I. Larkin, A. I. Larkin, G. Remenyi, H. Matsukawa, J. L. Tucker, J. P. Harrison, Ji-Min Duan, K. Maki, M. E. Itkis, N. I. Baklanov, P. Monceau, S. Abe, S. Brazovskii, S. V. Zaitsev-Zotov, S. V. Zaitsev-Zotov, S. V. Zaitsev-Zotov, T. Nattermann, T. Takoshima, Yu. N. Ovchinnikov   +18 more
core   +1 more source

Thermal rounding exponent of the depinning transition of an elastic string in a random medium [PDF]

, 2012
We study numerically thermal effects at the depinning transition of an elastic string driven in a two-dimensional uncorrelated disorder potential. The velocity of the string exactly at the sample critical force is shown to behave as $V \sim T^\psi$, with
A. B. Kolton, S. Bustingorry, T. Giamarchi, T. Giamarchi, T. Giamarchi   +4 more
core   +3 more sources

Creep Characteristics of Liquid Crystal Polymer Film

Journal of the Society of Materials Science, Japan, 2010
This paper studies the creep characteristic of a liquid crystal polymer (LCP) thin film. Tensile creep tests were performed using three directional specimens at three testing temperatures. Creep curves consisted of mainly transient creep and almost no steady and accelerated creep stages were found.
Hideyuki KANAYAMA, Shengde ZHANG, Masao SAKANE, Tadashi NAGASAWA, Kaoru KOBAYASHI   +4 more
openaire   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Study on creep characteristics of fractured rock masses in caved zones with different roof strengths

Dizhi lixue xuebao
Objective  The caved zone in goaf areas is filled with fractured rock masses, and the strength of these fractured rock masses after collapse serves as a key factor causing differential long-term creep characteristics of the goaf.
CAI Guanjun, WU Qiong, LIU Yunrong, LI Yidan   +3 more
doaj   +1 more source

Current--Voltage Characteristics of Two--Dimensional Vortex Glass Models

, 1994
We have performed Monte Carlo simulations to determine current--voltage characteristics of two different vortex glass models in two dimensions. The results confirm the conclusions of earlier studies that there is a transition at $T=0$.
A. I. Larkin, A. P. Young, A. P. Young, C. Dekker, C. Dekker, D. S. Fisher, H. Kleinert, H. Nishimori, J. D. Reger, J. V. José, J. Villain, K. B. Kim, K. H. Lee, K. K. Mon, M. Cieplak, M. J. P. Gingras, M. P. A. Fisher, M. P. A. Fisher, M. P. A. Fisher, M. Wallin, Mats Wallin, P. L. Gammel, R. A. Hyman, R. H. Koch, S. M. Girvin, S. Shenoy, Y H Li   +26 more
core   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Low frequency creep in CoNiFe films [PDF]

The results of an investigation of domain wall motion excited by slow rise-time, bipolar, hard-axis pulses in vacuum deposited CoNiFe films 1500A to 2000A thick are presented.
Bartran, D. S., Bourne, H. C., Jr., Chow, L. G.   +2 more
core   +1 more source