Results 41 to 50 of about 15,621 (262)

Creep constitutive model of strain energy density considering the whole process of creep deformation.

PLoS ONE
Aiming at the problem that the traditional creep model is difficult to reflect the characteristics of accelerated creep stage of rock, the influence of stress state on accelerated creep is fully considered, and a constitutive model which can describe ...
Yuemei Li
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Creep damage constitutive model of rock based on the mechanisms of crack-initiated damage and extended damage

Underground Space
Since the classical element model cannot describe the nonlinear characteristics of rock during the entire compressive creep process, nonlinear elements and creep damage are generally introduced in the model to resolve this issue.
Tianbin Li, Chao Chen, Feng Peng, Chunchi Ma, Mou Li, Yixiang Wang   +5 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Viscoelastic-plastic damage creep model for rock

Yantu gongcheng xuebao, 2020
Based on the classical element model, the nonlinear element and the creep damage are introduced to solve the problem that the classical element model cannot describe the non-linear characteristics of rock during the whole compressive creep process ...
ZHANG Liang-liang , WANG Xiao-jian
doaj   +1 more source

Undrained Creep Characteristics of Silty Sands and Comparative Study of Creep model

Journal of The Korean Society of Agricultural Engineers, 2012
Soils exhibit creep behavior in which deformation and movement proceed under a state of constant stress or load. In this study, A series of triaxial tests were performed under constant principal stress in order to interpret the undrained creep characteristics of silty sands.
Tae-Ho Bong, Young-Hwan Son, Soo-Kack Noh, Jae-Sung Park   +3 more
openaire   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Creep behavior of layered salt rock under triaxial loading and unloading cycles

Applied Rheology, 2023
This paper presents an extensive laboratory investigation of layered salt rocks under triaxial loading and unloading cycles aiming to better understand their viscoelastic plasticity strain characteristics.
Zhao Yanlin, Wang Xiaguang, Tang Wenyu, Li Yang, Lin Hang, Wang Yixian, Zhang Lianyang   +6 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source