Results 111 to 120 of about 4,982 (304)
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
An evaluation of operation and creep life of stationary gas turbine engine [PDF]
, 2012 During operation, gas turbine components undergo various types of timedependent degradation due to high temperatures and mechanical loading. In the case of stationary GT engines for mechanical power, creep failure mechanism problems are a very common ...
Eshati, Samir
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Mechanical Engineering JournalP91 steel, known for its excellent creep strength and corrosion resistance, is used in key high-temperature equipment in power plants. This equipment has geometric discontinuities such as notches, where cracks will develop due to creep-fatigue loading by
Akihiro MOTOKI, Masayuki ARAI
doaj +1 more source
Creep and Creep-Fatigue Crack Growth in Aluminium Alloys
, 2011 Due to the low melting point of aluminium and its consequences on microstructural stability and mechanical resistance, aluminium alloys are generally not considered for applications that have to withstand elevated temperatures in service. However, in some very specific instances where the temperature is not too high, aluminium alloys can present a ...
Gilbert Hnaff +2 more
openaire +2 more sources
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Numerical analysis of creep crack growth experiments
, 2022 S.477-481 : Abb.,Lit.The safety analysis and the life prediction of high-temperature components with defects (flaws, cracks, ...) have to take creep crack growth into account.
Hollstein, T., Kienzler, R.
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MetalsTesting and the estimation methods for predicting the life of crack initiation and crack growth for P92 steel using a circular sharp notched round bar specimen (CNS) under strain-controlled creep and fatigue conditions have been reported previously.
A. Toshimitsu Yokobori +5 more
doaj +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi +2 more
wiley +1 more source
The development of finite element software for creep damage analysis
Creep deformation and failure in high temperature structures is a serious problem for industry and is becoming even more so under the current increasing pressures of power, economics and sustainability.
Liu, Dezheng
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