Results 91 to 100 of about 42,527 (308)

Insights on microstructure evolution of austenite welded joints subjected to creep-fatigue loading

open access: yesJournal of Materials Research and Technology
The crack growth behavior and microstructural evolution of 316H austenitic stainless steel welded joints subjected to load-controlled creep-fatigue crack growth at 550 °C was investigated in this study. A comprehensive analysis of the fracture mechanisms
Cong Li   +4 more
doaj   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

open access: yesFEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi   +7 more
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

Materials Properties of Modifeied Ni-Based Alloy [PDF]

open access: yesMetalurgija, 2007
The thermomechanical processing of NiMoCr solid solution nickel base superalloy is the way to considerably influence the grain size. As uniform coarse grain size increases the creep strength and crack growth resistance.
Kraus, L.   +3 more
doaj  

Average crack-front velocity during subcritical fracture propagation in a heterogeneous medium [PDF]

open access: yes, 2011
We study the average velocity of crack fronts during stable interfacial fracture experiments in a heterogeneous quasibrittle material under constant loading rates and during long relaxation tests. The transparency of the material (polymethylmethacrylate)
Ampuero, J. P.   +7 more
core   +4 more sources

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

open access: yesFEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida   +6 more
wiley   +1 more source

Statistical Physics of Rupture in Heterogeneous Media [PDF]

open access: yes, 2005
The damage and fracture of materials are technologically of enormous interest due to their economic and human cost. They cover a wide range of phenomena like e.g.
Sornette, D.
core   +3 more sources

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

open access: yesFEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa   +2 more
wiley   +1 more source

The development of creep damage constitutive equations for low Cr-Mo alloy steel and its weldment at low stress [PDF]

open access: yes, 2013
The ultimate objective of this research project is to develop creep damage constitutive equations for low Cr-Mo alloy and its weldment under low stress (0.2-0.4 yield stress,σ_Y).
Lu, Zhongyu, Xu, Qiang, Xu, Qihua
core  

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

open access: yesFEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel   +8 more
wiley   +1 more source

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