Results 91 to 100 of about 4,982 (304)

A Review of Creep Deformation and Rupture Mechanisms of Cr-Mo Alloy for the Development of Creep Damage Constitutive Equations under Lower Stress

, 2013
This paper presents a review of creep deformation and rupture mechanisms of low Cr-Mo alloy for the development of its creep damage constitutive equations under lower stress.
Xu, Qiang, Barrans, Simon, Xu, Qihua, Lou, Zhongyu, Lu, Zhongyu   +4 more
core  

Effect of circular holes on the ratchet limit and crack tip plastic strain range in a centre cracked plate

, 2011
In this paper a centre cracked plate subjected to cyclic tensile loading and cyclic bending moment is considered. The effect of circular holes drilled in the region of the crack tip on the ratchet limit and crack tip plastic strain range is studied ...
Ure, James Michael, James Ure, Haofeng Chen, Chen, Haofeng, Li, Tianbai, Tianbai Li, Weihang Chen, Chen, Weihang   +7 more
core   +1 more source

Insights on microstructure evolution of austenite welded joints subjected to creep-fatigue loading

Journal of Materials Research and Technology
The crack growth behavior and microstructural evolution of 316H austenitic stainless steel welded joints subjected to load-controlled creep-fatigue crack growth at 550 °C was investigated in this study. A comprehensive analysis of the fracture mechanisms
Cong Li, Lei Zhao, Lianyong Xu, Yongdian Han, Kangda Hao   +4 more
doaj   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Design and Assessment for Creep-Fatigue and Creep-Fatigue Crack Growth

, 2016
Creep-fatigue assessments require inputs for both creep damage and fatigue damage. Then these damage terms are combined using some form of interaction diagram to enable estimation of the creep-fatigue life.
Robert A. Ainsworth, Ainsworth, Robert
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Modeling creep crack growth in high chromium steels

, 2014
Components used in power generation plants are continually exposed to high temperatures and risk of failure resulting from net section rupture, creep crack growth or fatigue crack growth.
ESPOSITO, Luca, Dichiaro S, Folgarait P., Bonora N   +3 more
core  

Materials Properties of Modifeied Ni-Based Alloy [PDF]

Metalurgija, 2007
The thermomechanical processing of NiMoCr solid solution nickel base superalloy is the way to considerably influence the grain size. As uniform coarse grain size increases the creep strength and crack growth resistance.
Kraus, L., Zrník, J., Wangyao, P., Němeček, S.   +3 more
doaj  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source