Results 81 to 90 of about 42,527 (308)

Nonlocal Approach to CAFE Solution of Creep Crack Growth Problem

Engineering Transactions, 2016
Solving a creep crack growth problem using the CAFE methodology encounters the problems typical of other local methods. This article presents a nonlocal grid method applied in order to regularize these problems.
Krzysztof NOWAK
doaj   +1 more source

Damage tolerance issues peculiar to supersonic civil transport aircraft

, 2005
International audienceThis paper presents results of experimental investigations on creep, fatigue and creep-fatigue crack growth behaviour of the 2650-T6 aluminium alloy in temperature, along with numerical simulation of stress distribution around the ...
Haddar, Nader, Hénaff, Gilbert, Journet, Bertrand, Köster, Alain, Odemer, Grégory, Rémy, Luc   +5 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Creep Crack Growth Behavior during Hot Water Immersion of an Epoxy Adhesive Using a Spring-Loaded Double Cantilever Beam Test Method. [PDF]

Materials (Basel), 2023
Nakamura K, Sekiguchi Y, Shimamoto K, Houjou K, Akiyama H, Sato C.   +5 more
europepmc   +1 more source

Elevated temperature crack growth [PDF]

The purpose of this program was to extend the work performed in the base program (CR 182247) into the regime of time-dependent crack growth under isothermal and thermal mechanical fatigue (TMF) loading, where creep deformation also influences the crack ...
Kim, K. S., Vanstone, R. H.
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Fatigue crack propagation of nickel-base superalloys at 650 deg C [PDF]

The 650 C fatigue crack propagation behavior of two nickel-base superalloys, Rene 95 and Waspaloy, is studied with particular emphasis placed on understanding the roles of creep, environment, and two key grain boundary alloying additions, boron and ...
Gabb, T. P., Gayda, J., Miner, R. V.
core   +1 more source

Practical considerations of the use of cross-weld and compact tension specimens creep data [PDF]

, 2016
This article gives an overview of the use of cross-weld and compact tension specimen modelling and analyses data to characterise creep behaviour of the high-temperature components. Cross-weld and compact tension specimens are used to describe creep crack
Davies CM, Halighongde S., Hyde TH, Hyde TH, Hyde TH, Hyde TH, Hyde TH, Hyde TH, Hyde TH, Irwin GR., Kachanov LM., Liu Y, Schuller HJ, Tanner DWJ   +13 more
core   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source