Results 71 to 80 of about 42,527 (308)

Estimation of crack progration dynamics in WWER-1000 core barrel taking into account combined effect of high temperature, static loading and neutron irradiation [PDF]

, 2015
Розглянуто питання про поширення тріщини в шахті водо-водяного ядерного реактора ВВЕР-1000. Побудовано рівняння швидкості поширення тріщини в матеріалі за сумісної дії високої температури, силового навантаження та нейтронного опромінення, що добре описує
Andreykiv, Oleksandr, Dolinska, Iryna, Kukhar, Volodymyr, Андрейків, Олександр Євгенович, Долінська, Ірина Ярославівна, Кухар, Володимир Зиновійович   +5 more
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Fracture, Fatigue, and Structural Integrity of Metallic Materials

Metals, 2019
Fracture, fatigue, and other subcritical processes, such as creep crack growth or stress corrosion cracking, present numerous open issues from both scientific and industrial points of view [...]
Sergio Cicero, José Alberto Álvarez
doaj   +1 more source

Fractal frontiers of bursts and cracks in a fiber bundle model of creep rupture

, 2015
We investigate the geometrical structure of breaking bursts generated during the creep rupture of heterogeneous materials. Based on a fiber bundle model with localized load sharing we show that bursts are compact geometrical objects, however, their ...
Danku, Zsuzsa, Herrmann, Hans J., Kun, Ferenc   +2 more
core   +1 more source

Creep crack growth behavior of P91 steel weldments

Thermal Science, 2019
The steels operating at elevated temperatures are well known to be exposed to premature failure due to cracking caused by constant thermal stress, i.e. secondary creep process. Therefore, creep crack growth (CCG) tests were carried out on compact tension (CT) specimens machined from P91 weld joint at 600°C to determine its behaviour in realistic ...
Swei, Mohamed, Sedmak, Aleksandar, Petrovski, Blagoj, Golubović, Zorana, Sedmak, Simon, Katinić, Marko, Azzabi, Khaled I.   +6 more
openaire   +4 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Deformation and fracture characteristics of rock under creep-impact loading based on subcritical crack growth

Meitan xuebao
During deep resources extraction, deep rock is subjected to high stress and dynamic disturbances, leading to frequent dynamic disasters such as coal rock bursts that severely restrict the safe and efficient production of deep resources.
Guangchao ZHANG, Zesen ZHOU, Guanglei ZHOU, Tao XU, KONIETZKY Heinz, Xipo ZHAO, He HUANG, Yuhang LIU   +7 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Modeling the creep damage effect on the creep crack growth behavior of rotor steel

Open Physics, 2018
To evaluate the fracture life of steam turbine HP-IP rotors more accurately, an understanding of the creep damage effect on creep cracking performance of service-exposed rotor steel, and a proper creep crack growth (CCG) model considering the creep ...
Ye Ting, Wang Zhengdong, Xuan Fu-Zhen
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source