Results 71 to 80 of about 4,982 (304)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Creep Fatigue Crack Growth and Creep Crack Growth Behavior of P92 at Elevated Temperature

, 2022
High chromium heat resistant steels are commonly used for boiler components that are operated around 600ºC in ultra-supercritical (USC) thermal power plants.
DeSantis, Anthony
core  

Fracture, Fatigue, and Structural Integrity of Metallic Materials

Metals, 2019
Fracture, fatigue, and other subcritical processes, such as creep crack growth or stress corrosion cracking, present numerous open issues from both scientific and industrial points of view [...]
Sergio Cicero, José Alberto Álvarez
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Creep: time‐dependent brittle deformation in rocks

, 2009
The characterization of time‐dependent brittle rock deformation is fundamental to understanding the long‐term evolution and dynamics of the Earth’s crust. The chemical influence of pore water promotes time‐dependent deformation through stress corrosion
Heap, M.J.
core  

Creep Crack Growth Behavior during Hot Water Immersion of an Epoxy Adhesive Using a Spring-Loaded Double Cantilever Beam Test Method. [PDF]

Materials (Basel), 2023
Nakamura K, Sekiguchi Y, Shimamoto K, Houjou K, Akiyama H, Sato C.   +5 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Creep-Fatigue Crack Growth in Power Plant Components [PDF]

, 2017
In components operating at high temperature, the presence of defect, that may derive from manufacturing process or operating under critical conditions, could raise to creep-fatigue crack growth even at low loading conditions.
A. Lo Conte, M. Cristea, F. Bassi, S. Beretta   +3 more
core  

Crack Propagation Process of Concrete Under Sustained Loading with DIC Technique

Buildings
Concrete structures frequently experience sustained loading during service, which may lead to crack propagation and eventual failure. In this study, three-point bending beams with heights of 200 mm and 300 mm were subjected to sustained load levels of 0 ...
Xiaoyan Han, Hongwei Wang, Hongbo Gao, Rena C. Yu, Zhimin Wu   +4 more
doaj   +1 more source

Modeling the creep damage effect on the creep crack growth behavior of rotor steel

Open Physics, 2018
To evaluate the fracture life of steam turbine HP-IP rotors more accurately, an understanding of the creep damage effect on creep cracking performance of service-exposed rotor steel, and a proper creep crack growth (CCG) model considering the creep ...
Ye Ting, Wang Zhengdong, Xuan Fu-Zhen
doaj   +1 more source