Results 61 to 70 of about 4,982 (304)

Physical-Mechanism Exploration of the Low-Cycle Unified Creep-Fatigue Formulation

Metals, 2017
Background—Creep-fatigue behavior is identified as the incorporated effects of fatigue and creep. One class of constitutive-based models attempts to evaluate creep and fatigue separately, but the interaction of fatigue and creep is neglected.
Dan Liu, Dirk John Pons
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

The Interpretation of Experimental Observation Data for the Development of Mechanisms based Creep Damage Constitutive Equations for High Chromium Steel

, 2015
It is very important to design a safe factor or estimating the remain lifetime for electric power plant components of steam pipes which mostly manufacture by high chromium steels and work at high temperature and low stress level.
Yang, Xin, Xu, Qiang, Xin Yang, Zhongyu Lu, Qiang Xu, Lu, Zhongyu   +5 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Creep Crack Growth Test Method and Creep Crack Growth Properties for TiAl Intermetallic Compound.

Journal of the Society of Materials Science, Japan, 2000
VAMAS project which aims to establish the standard test method of creep crack growth for creep brittle advanced materials is being conducted. The round robin tests on TiAl intermetallic compound with fully lamellar structure were carried out. Based on the results of round robin, the recommended test method was proposed.
TABUCHI, Masaaki, YOKOBORI, Toshimitu, FUJI, Akio, KUBO, Kiyoshi, YAGI, Koichi, YOKOBORI, Takeo   +5 more
openaire   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Recent advances in modelling creep crack growth

, 2022
At the time of the previous International Conference on Fracture, the C integral had long been recognized as a promising load parameter for correlating crack growth rates in creep-ductile materials.
Riedel, H.
core  

Holistic Approach on the Research of Yielding, Creep and Fatigue Crack Growth Rate of Metals Based on Simplified Model of Dislocation Group Dynamics

Metals, 2020
The simplified model of numerical analyses of discrete dislocation motion and emission from a stressed source was applied to predict the yield stress, dislocation creep, and fatigue crack growth rate of metals dominated by dislocation motion. The results
A. Toshimitsu Yokobori
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Deformation and fracture characteristics of rock under creep-impact loading based on subcritical crack growth

Meitan xuebao
During deep resources extraction, deep rock is subjected to high stress and dynamic disturbances, leading to frequent dynamic disasters such as coal rock bursts that severely restrict the safe and efficient production of deep resources.
Guangchao ZHANG, Zesen ZHOU, Guanglei ZHOU, Tao XU, KONIETZKY Heinz, Xipo ZHAO, He HUANG, Yuhang LIU   +7 more
doaj   +1 more source