Results 101 to 110 of about 42,527 (308)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

The Fracture Mechanics Concept of Creep and Creep/Fatigue Crack Growth in Life Assessment

International Journal of Industrial Engineering and Production Research, 2006
There is an increasing need to assess the service life of components containing defect which operate at high temperature. This paper describes the current fracture mechanics concepts that are employed to predict cracking of engineering materials at high ...
F.D. Javanroodi, K. M. Nikbin
doaj  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

STUDY ON THE SLOW CRACK GROWTH BEHAVIOR OF PE100 PIPE

Jixie qiangdu, 2019
In this article,fatigue crack growth（ FCG） experiments were conducted on cracked round bar（ CRB）specimens manufactured from PE100 pipes at different R-ratios.
DU ZhaoXin, DONG JunHua, GAO BingJun
doaj  

Time dependent fracture of polymers [PDF]

, 1989
The fracture behavior of polymers is reviewed with emphasis on the time dependent aspects of the problem. Following a delineation of the history of crack propagation investigations in linearly viscoelastic materials, the effects of temperature and ...
Knauss, W. G.
core  

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Inelastic finite element analysis of circumferentially notched specimen by damage-coupled inelastic constitutive equation of P91 steel

Mechanical Engineering Journal
P91 steel, known for its excellent creep strength and corrosion resistance, is used in key high-temperature equipment in power plants. This equipment has geometric discontinuities such as notches, where cracks will develop due to creep-fatigue loading by
Akihiro MOTOKI, Masayuki ARAI
doaj   +1 more source

Creep and creep-fracture crack growth

, 1989
Imperial Users ...
Djavanroodi, Faramarz, Djavanroodi, Faramarz   +1 more
openaire   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source