Results 51 to 60 of about 8,285 (310)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

A thickness debit effect characterization parameter for creep rupture behaviors of nickel-based single crystal superalloys

Journal of Materials Research and Technology
Creep rupture tests were conducted on 67 thin-walled DD6 specimens, with thicknesses ranging from 0.35 mm to 1.50 mm, at temperatures of 760 °C, 850 °C, 980 °C, and 1100 °C, revealing a log-linear relationship between rupture lifetimes and specimen ...
Yue Zhang, Ruida Xu, Jiangkun Hu, Wei Xu, Yuhuai He, Huichen Yu   +5 more
doaj   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Evaluation of Plasticity and Creep Parameters From Tensile Stress–Strain Data for a Range of Strain Rates

Advanced Engineering Materials, EarlyView.
This plot compares experimental tensile stress–strain curves (with 4 different strain rates) and corresponding modelled curves (obtained using the optimised sets of Voce and Miller–Norton parameter values shown). The inferred M‐N values, characterizing the creep, are very similar to those obtained via conventional creep testing.
S. Ooi, R. P. Thompson, T. W. Clyne
wiley   +1 more source

Experimental Characterization of Mycelium‐Based Composites Under Multiple Loading Conditions

Advanced Engineering Materials, EarlyView.
This study examines the mechanical response of mycelium‐based composites under compression, shear, and tension using mechanical testing and imaging methods. The comparison between unpressed and hot‐pressed specimens shows that hot pressing is associated with higher compression and shear stiffnesses.
Shaghayegh Elahi, Kimiya Tajik, Harvey Shaw, Matti Isakov, Sami Pajunen, Lauri Rautkari   +5 more
wiley   +1 more source

Lifetime evaluation of concrete structures under sustained post-peak loading [PDF]

, 2005
Experimental tests on crack propagation in concrete under constant post-peak loading are simulated using the finite element method and the cohesive crack model, in both Mode I and Mixed-mode conditions.
Silvio Valente, Fabrizio Barpi, Barpi, Fabrizio, Valente, Silvio   +3 more
core   +1 more source

Advanced Electron Microscopy and Microcomputed Tomography Analysis of Single‐Crystal Ni‐Base Superalloys After Short‐Term Multiaxial Creep

Advanced Engineering Materials, EarlyView.
This work studies the anisotropic behavior of circular notched tensile specimens of Ni‐base superalloy single crystals during high‐temperature tensile creep along [001], [110], and [111]. Correlative scale‐bridging imaging of specimens reveals early rupture along [110] because 1) plastic deformation proceeds faster at notch center; 2) more (brittle ...
Leonardo Agudo Jácome, Lijie Cao, Christoph Somsen, Johannes Boes, René Hesse, Werner Theisen, Gunther Eggeler   +6 more
wiley   +1 more source

A Review of Creep Deformation and Rupture Mechanisms of Cr-Mo Alloy for the Development of Creep Damage Constitutive Equations under Lower Stress

, 2013
This paper presents a review of creep deformation and rupture mechanisms of low Cr-Mo alloy for the development of its creep damage constitutive equations under lower stress.
Xu, Qiang, Barrans, Simon, Xu, Qihua, Lou, Zhongyu, Lu, Zhongyu   +4 more
core  

A Skin‐Like Strain Sensor for Real‐Time Human Motion Detection

Advanced Functional Materials, EarlyView.
A skin‐like strain sensor with exceptional flexibility and breathability enables real‐time human motion detection. It offers continuous ECG monitoring and gesture recognition, ensuring high durability and comfort. This innovative design is ideal for wearable applications, combining reliable performance with seamless integration into dynamic ...
Shiqi Song, Zhe Li, Jingya Guo, Shuo Shi, Jian Fang, Xungai Wang   +5 more
wiley   +1 more source

Creep Rupture Life Prediction Based on Analysis of Large Creep Deformation

Journal of Aeronautical Materials, 2016
A creep rupture life prediction method for high temperature component was proposed. The method was based on a true stress-strain elastoplastic creep constitutive model and the large deformation finite element analysis method. This method firstly used the
YE Wenming, HU Xuteng, MA Xiaojian, SONG Yingdong   +3 more
doaj   +1 more source