Results 31 to 40 of about 8,285 (310)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Effects of Heat Treatment and Crystallographic Orientation on Creep Behavior of Aluminized Nickel-Base Single Crystal Superalloy CM186LC

International Journal of Electrochemical Science, 2012
The effect of heat treatment and crystallographic orientation on creep behavior of aluminized Ni-base single crystal superalloy CM186LC has been investigated in the present study. The aluminized superalloy has a better creep rupture life after HT2 rather
Fahamsyah H. Latief, Koji Kakehi
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Performance based creep life estimation for gas turbines application [PDF]

, 2011
Accurate and reliable component life prediction is crucial to ensure both the safety and economics of gas turbine operations. In the pursuit of improved accuracy and reliability, current model-based creep life estimation methods have become more and ...
Abdul Ghafir, Mohammad Fahmi Bin
core  

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Effect of Tungsten on Creep Behavior of 9%Cr–3%Co Martensitic Steels

Metals, 2017
The effect of increasing tungsten content from 2 to 3 wt % on the creep rupture strength of a 3 wt % Co-modified P92-type steel was studied. Creep tests were carried out at a temperature of 650 °C under applied stresses ranging from 100 to 220 MPa with a
Alexandra Fedoseeva, Nadezhda Dudova, Rustam Kaibyshev, Andrey Belyakov   +3 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Description of creep rupture strength of tensile rod with rectangular and circular cross-section at high temperature air media

Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2013
Description of known experimental data on the creep rupture strength of tensile rectangular and circular cross-sections rods at high temperature in air media is considered. Simulation of the creep rupture strength of tensile specimens is based on the Yu.
L. V. Fomin
doaj   +3 more sources

Small Two-Bar Specimen Creep Testing of Grade P91 Steel at 650°C

High Temperature Materials and Processes, 2016
Commonly used small creep specimen types, such as ring and impression creep specimens, are capable of providing minimum creep strain rate data from small volumes of material. However, these test types are unable to provide the creep rupture data. In this
Ali Balhassn S. M., Hyde Tom H., Sun Wei
doaj   +1 more source