Results 91 to 100 of about 29,749 (223)

Endocannabinoid system gene expression in mesocorticolimbic brain regions of individuals with alcohol use disorder: A descriptive study

Addiction, Volume 121, Issue 5, Page 1179-1189, May 2026.
Abstract Aims To describe differences in the expression of genes encoding cannabinoid receptors (CNR1, CNR2), the associated receptor GRP55 and the enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MGLL) between individuals with alcohol use disorder (AUD) and controls in key mesocorticolimbic brain regions.
María Salud García‐Gutiérrez, Abraham Bailén Torregrosa, Francisco Navarrete, Auxiliadora Aracil‐Fernández, Gabriel Rubio, Jorge Manzanares   +5 more
wiley   +1 more source

Evidence for different seeding activities of misfolded tau in classical and rapidly progressive Alzheimer's disease

Brain Pathology, Volume 36, Issue 3, May 2026.
The study analyzed the seeding activity of misfolded tau protein in Alzheimer's disease and rapidly progressive Alzheimer's disease patients and provides evidence for the existence of different tau assemblies supported by differences in cellular toxicity and morphology of thioflavin T‐positive real‐time quaking‐induced conversion products.
Matthias Schmitz, Katrin Thüne, Anna‐Lisa Fischer, Peter Hermann, Maria Cramm, Leonie Sheila Kadel, Wiebke Möbius, Jakob Matschke, Tayyaba Saleem, Neelam Younas, Saima Zafar, Hermann Altmeppen, Markus Glatzel, Inga Zerr   +13 more
wiley   +1 more source

Review: Creutzfeldt‐Jakob Disease

Brain Pathology, 1996
The clinicopathological spectrum of Creutzfeldt‐Jakob disease has recently been extended by the identification of an apparently new variant of this disorder in the UK. The hypothesis that this new disorder is causally related to the transmissible agent responsible for bovine spongiform encephalopathy has prompted re‐evaluation of the relationships ...
openaire   +2 more sources

Dental treatment and risk of variant CJD - a case control study [PDF]

, 2007
Objective: Knowledge of risk factors for variant CJD (vCJD) remains limited, but transmission of prion proteins via re-useable medical devices, including dental instruments, or enhanced susceptibility following trauma to the oral cavity is a concern ...
A. J. Smith, AH Lowe, AH Peden, AJ Smith, CA Llewelyn, CM Van Duijn, D. Everington, ER Mulcahy, F Blanquet-Grossard, H. J. T. Ward, HJT Ward, HJT Ward, J. Bagg, JC Bartz, K Kondo, L Ingrosso, MW Head, R. G. Will, RG Will, S Collins, S. Letters, Z Davinpour   +21 more
core   +1 more source

Mathematical Models for Estimating the Risk of vCJD Transmission [PDF]

, 2009
We present two different simple models for vCJD transmission by blood transfusion. Both models indicate that transfusions alone are unlikely to cause more than a few infections, unless the number of primary cases increases.
Anvari, V., Atapour, M., Bourouiba, L., Caudillo Mata, L. A., Collinson, S., Johnson, A., Madras, N., Miasnikof, P., Ramirez Ramirez, L. L., Sanchez-Bravo, I.   +9 more
core  

Evolution of Diffusion-Weighted Magnetic Resonance Imaging Signal Abnormality in Sporadic Creutzfeldt-Jakob Disease, With Histopathological Correlation [PDF]

, 2015
IMPORTANCE: Prion diseases represent the archetype of brain diseases caused by protein misfolding, with the most common subtype being sporadic Creutzfeldt-Jakob disease (sCJD), a rapidly progressive dementia.
Brandner, S, Carswell, CJ, Collinge, J, Eisenmenger, L, Hyare, H, Jäger, HR, Mead, S, Porter, MC, Rudge, P, Thompson, A   +9 more
core   +1 more source

Sporadic Creutzfeldt-Jakob disease: Clinical, pathological and molecular study [PDF]

Revista Ciencias de la Salud, 2008
phalopathiesare neurodegenerative diseasescaused by abnormal accumulation of pathogenicisoform the prion protein, which induces theformation of conglomerates protein resistantto degradation.
Victoria Eugenia Villegas, Fernando Velandia, Cesar Payán   +2 more
doaj  

Treating seizures in Creutzfeldt–Jakob disease

Epilepsy and Behavior Case Reports, 2014
Seizures are known to occur in Creutzfeldt–Jakob disease (CJD). In the setting of a rapidly progressive condition with no effective therapy, determining appropriate treatment for seizures can be difficult if clinical morbidity is not obvious yet the ...
Marcus C. Ng, M. Brandon Westover, Andrew J. Cole   +2 more
doaj   +1 more source

Progressive multifocal diffusion-weighted imaging hyperintensities in sporadic Creutzfeldt–Jakob disease with positive cerebrospinal fluid real-time quaking-induced conversion: a case report

Journal of Medical Case Reports
Background Creutzfeldt–Jakob disease is a rare and invariably fatal neurodegenerative disorder classified among the prion diseases. Primarily affecting the brain, this condition precipitates neuronal cell demise, culminating in swiftly advancing dementia
Puyu Li, Wenjing Wang, Lingzhi Li, Keding Cheng, Ying Wang, Yuanyuan Li, Wei Xu   +6 more
doaj   +1 more source

The first reported case of Creutzfeldt‐Jakob disease from Nepal

Clinical Case Reports, 2020
Creutzfeldt‐Jakob disease (CJD) can also be diagnosed in a resource‐limited setting through good clinical analysis. The diagnosis of CJD should be considered in patients with rapidly evolving neurological signs associated with cognitive disturbances even
Himal Kharel, Pabitra Adhikari, Nishan B. Pokhrel, Zeni Kharel, Gaurav Nepal   +4 more
doaj   +1 more source