Results 71 to 80 of about 29,749 (223)

The L108I polymorphism in mouse prion protein drives spontaneous disease and enhances transmission of atypical and classical prion strains

Brain Pathology, EarlyView.
A single amino acid change (L108I) combined with PrP overexpression drives spontaneous atypical prion formation in mice, enabling also efficient propagation of diverse prion strains. This model allows studying how spontaneous prion diseases arise and provides powerful tools for investigating strain emergence, transmission barriers, and mechanisms ...
Hasier Eraña, Enric Vidal, Natalia Fernández‐Borges, Jorge M. Charco, Carlos M. Díaz‐Domínguez, Cristina Sampedro‐Torres‐Quevedo, Josu Galarza‐Ahumada, Eva Fernández‐Muñoz, Maitena San‐Juan‐Ansoleaga, Miguel Ángel Pérez‐Castro, Nuno Gonçalves‐Anjo, Patricia Piñeiro, Samanta Giler, Nora González‐Martín, Nuria L. Lorenzo, Africa Manero‐Azua, Guiomar Perez de Nanclares, Mariví Geijo, Manuel A. Sánchez‐Martín, Jesús R. Requena, Joaquín Castilla   +20 more
wiley   +1 more source

Human brain matters: Navigating the neuropathology of COVID‐19

Brain Pathology, EarlyView.
Severe COVID‐19 is associated with vascular dysregulation and chronic neuroinflammation, leading to axonal injury and neurodegeneration. In long COVID or PASC, persistent alterations in neuroimaging and biofluid biomarkers reflect ongoing neuronal damage and neuroinflammation, contributing to long‐term neurological symptoms including fatigue, cognitive
Juliana M. Nieuwland, Angelica Scaramuzza, Marianna Bugiani, Wilma D. J. van de Berg, Jinte Middeldorp   +4 more
wiley   +1 more source

Creutzfeldt-Jakob disease: recent developments [PDF]

F1000Research, 2017
Creutzfeldt-Jakob disease (CJD) is a rare prion disorder that has been the subject of both professional and public interest following the identification of variant CJD as a zoonotic disorder. There have been recent advances in diagnostic techniques, including real-time quaking-induced conversion and magnetic resonance imaging brain scan, that have ...
Graeme Mackenzie, Robert Will
openaire   +3 more sources

Diagnosis of Methionine/Valine Variant Creutzfeldt-Jakob Disease by Protein Misfolding Cyclic Amplification [PDF]

, 2018
A patient with a heterozygous variant of Creutzfeldt-Jakob disease (CJD) with a methionine/valine genotype at codon 129 of the prion protein gene was recently reported.
Bougard, Daisy, Bruyère-Ostells, Lilian, Bélondrade, Maxime, Fournier-Wirth, Chantal, Green, Alison J E, Knight, Richard S, Lehmann, Sylvain, Mayran, Charly, Will, Robert G   +8 more
core   +3 more sources

Motives and barriers to blood donation among adults aged over 50 years: A qualitative analysis

Transfusion Medicine, EarlyView.
Abstract Background Ageing populations will increase demand for blood‐products and donors who supply them. While blood collection agencies (BCAs) typically target younger people to expand supply, recruiting donors aged 50+ is also a potential solution. However, few studies focus exclusively on this group.
Melissa K. Hyde, Barbara M. Masser, Rachel Thorpe, Aaron Akpu Philip, Amanda Salmon, Theresa L. Scott, Tanya E. Davison   +6 more
wiley   +1 more source

Clinical perspectives of emerging pathogens in bleeding disorders. [PDF]

, 2006
As a result of immunological and nucleic-acid screening of plasma donations for transfusion-transmissible viruses, and the incorporation of viral reduction processes during plasma fractionation, coagulation-factor concentrates (CFC) are now judged safe ...
Bozzette, Samuel, Diamond, Michael, Koerper, Marion A, Kulkarni, Roshni, Ludlam, Christopher A, Powderly, William G, Ritchie, Bruce, Siegel, Jamie, Simmonds, Peter, Stanley, Samuel, Tapper, Michael L, von Depka, Mario   +11 more
core   +1 more source

Creutzfeldt‐Jakob‐Like Presentation in Anti‐AMPAR Encephalitis

Annals of Neurology, EarlyView.
Kate Durbano, Marie Belley, Delphine Leclercq, Louis Cousyn   +3 more
wiley   +1 more source

Addressing racial disparities in representation across blood, stem cell and organ and tissue donor pools

Vox Sanguinis, EarlyView.
Abstract Background and Objectives Adequate representation of donors from diverse ancestral populations in blood, stem cell and organ transplantation is critical to ensuring equitable access to these lifesaving therapies. Because of population‐level differences in genetic markers, patients from racialized groups may have unique transfusion and ...
Bonnie Lu, Sylvia Okonofua, Farnaz Farahbakhsh, Rupal Hatkar, Lauren Sano, Margarita Conway, Marie‐Claire Kapesa, Manuel Escoto, Murdoch Leeies, Warren B. Fingrut   +9 more
wiley   +1 more source

PRNP P39L variant is a rare cause of frontotemporal dementia in Iialian population [PDF]

, 2016
The missense P39L variant in the prion protein gene (PRNP) has recently been associated with frontotemporal dementia (FTD). Here, we analyzed the presence of the P39L variant in 761 patients with FTD and 719 controls and found a single carrier among ...
Arcaro, Marina, Arighi, Andrea, Arosio, Beatrice, Benussi, Luisa, Binetti, Giuliano, Bruno, Giuseppe, Bursey, Devan, Cioffi, Sara Mg, Confaloni, Annamaria, Fenoglio, Chiara, Fumagalli, Giorgio G, Galimberti, Daniela, Ghidoni, Roberta, Grande, Giulia, Kauwe, John S, Mari, Daniela, Mariani, Claudio, Nacmias, Benedetta, Oldoni, Emanuela, Pinessi, Lorenzo, Piscopo, Paola, Rainero, Innocenzo, Rubino, Elisa, Scarioni, Marta, Scarpini, Elio, Serpente, Maria, Sorbi, Sandro, Talarico, Giuseppina   +27 more
core   +2 more sources

Sporadic Creutzfeldt–Jakob Disease

Acta Medica Bulgarica
Sporadic Creutzfeldt–Jakob disease is a rare and fatal human prion disease characterized by a rapidly progressive dementia, myoclonus, cerebellar, pyramidal, extrapyramidal, visual, and psychiatric symptoms. These findings are all non-specific and making
Zhelyazkova S., Nachev S., Kalev O., Tournev I.   +3 more
doaj   +1 more source