Results 211 to 220 of about 52,471 (263)
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Actions of CRF and its Analogs
Current Medicinal Chemistry, 1999Corticotropin-releasing factor (CRF), urocortin, sauvagine and urotensin I form the CRF family. These peptides bind with different affinities to two subtypes of CRF receptor (CRFR), CRFR1 and CRFR2. The latter exists as two splice variants, the neuronal CRFR2a. and the peripheral CRFR2.
Jelena Radulovic +2 more
exaly +4 more sources
1999
Corticotropin-releasing factor (CRF), a 41-residue polypeptide, is one of the hypothalamic hypophysiotropic peptides. In mammals, CRF is synthesized in the hypothalamic paraventricular nucleus PVN, transported to the median eminence and secreted in the portal circulation reaching the corticotrophs of the anterior pituitary (Cummings et al.
J, Radulovic +5 more
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Corticotropin-releasing factor (CRF), a 41-residue polypeptide, is one of the hypothalamic hypophysiotropic peptides. In mammals, CRF is synthesized in the hypothalamic paraventricular nucleus PVN, transported to the median eminence and secreted in the portal circulation reaching the corticotrophs of the anterior pituitary (Cummings et al.
J, Radulovic +5 more
openaire +2 more sources
American Journal of Kidney Diseases, 2003
Alteration in liver function are not typically present in patients with uremic syndrome, but varying degrees of liver dysfunction were observed in animals with experimental uremia and, to a lesser degree, in patients with chronic renal failure. This article summarizes the data obtained during the last 2 decades on protein, carbohydrate, and lipid ...
Miroslaw J, Smogorzewski +1 more
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Alteration in liver function are not typically present in patients with uremic syndrome, but varying degrees of liver dysfunction were observed in animals with experimental uremia and, to a lesser degree, in patients with chronic renal failure. This article summarizes the data obtained during the last 2 decades on protein, carbohydrate, and lipid ...
Miroslaw J, Smogorzewski +1 more
openaire +2 more sources
CRF and CRF Receptors: Role in Stress Responsivity and Other Behaviors
Annual Review of Pharmacology and Toxicology, 2004Since corticotropin-releasing factor (CRF) was first characterized, a growing family of ligands and receptors has evolved. The mammalian family members include CRF, urocortinI (UcnI), UcnII, and UcnIII, along with two receptors, CRFR1 and CRFR2, and a CRF binding protein.
Tracy L, Bale, Wylie W, Vale
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Acta Endocrinologica, 1984
Abstract. The biological activity of ovine (o) and human (h) corticotrophin releasing factor (CRF) in normal volunteers was investigated. Nine subjects received an iv bolus injection of 50, 100 and 200 μg oCRF. There was no dose-response relationship between the injected oCRF dosage and stimulated ACTH, β-endorphin, and cortisol secretion. The addition
G K, Stalla +3 more
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Abstract. The biological activity of ovine (o) and human (h) corticotrophin releasing factor (CRF) in normal volunteers was investigated. Nine subjects received an iv bolus injection of 50, 100 and 200 μg oCRF. There was no dose-response relationship between the injected oCRF dosage and stimulated ACTH, β-endorphin, and cortisol secretion. The addition
G K, Stalla +3 more
openaire +2 more sources
2017
Chapter 5 explains how excessive fear is tied to anxiety disorders, and vulnerability to the breakdown of mental and physical health. CRF in the brain is tied to these events. CRF, for instance, may be constrained by the neurotransmitter GABA in key regions of the forebrain and is mobilized by brainstem catecholaminergic neurons that are critical in ...
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Chapter 5 explains how excessive fear is tied to anxiety disorders, and vulnerability to the breakdown of mental and physical health. CRF in the brain is tied to these events. CRF, for instance, may be constrained by the neurotransmitter GABA in key regions of the forebrain and is mobilized by brainstem catecholaminergic neurons that are critical in ...
openaire +1 more source
CRF and CRF-related peptides in stress adaptation: From invertebrates to man
General and Comparative Endocrinology, 2007Contains fulltext : 35048.pdf (Publisher’s version ) (Closed access)
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A Density Functional Study of the Structure and Stability of CrF4, CrF5, and CrF6
Inorganic Chemistry, 1996The structure and stability of VF(5) and the higher chromium fluorides CrF(4), CrF(5), and CrF(6) have been investigated using density functional theory. The local density approximation (LDA) was used to obtain geometries and vibrational frequencies, while nonlocal corrections were added in order to obtain more accurate binding energies.
L. G., Vanquickenborne +2 more
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Current opinion in investigational drugs (London, England : 2000), 2001
DuPont (formerly DuPont Merck), Neurocrine Biosciences and Cephalon are conducting a joint investigation into corticotropin releasingfactor (CRF) ligands. These compounds may have potential as antidepressants and anxiolytics. SV-030 and other analogs from the series are entering preclinical development [361291], [362064].
openaire +2 more sources
DuPont (formerly DuPont Merck), Neurocrine Biosciences and Cephalon are conducting a joint investigation into corticotropin releasingfactor (CRF) ligands. These compounds may have potential as antidepressants and anxiolytics. SV-030 and other analogs from the series are entering preclinical development [361291], [362064].
openaire +2 more sources