Results 101 to 110 of about 48,713 (266)

B-Raf and CRHR1 internalization mediate biphasic ERK1/2 activation by CRH in hippocampal HT22 Cells. [PDF]

, 2013
CRH is a key regulator of neuroendocrine, autonomic, and behavioral response to stress. CRH-stimulated CRH receptor 1 (CRHR1) activates ERK1/2 depending on intracellular context.
Holsboer, Florian, Maccarrone, Giuseppina, Silberstein, S., Inda, Carolina, Senin, Sergio Ariel, Refojo, Damian, Maccarrone, G., Silberstein Cuña, Susana Iris, Arzt, Eduardo Simon, Giacomini, D., Bonfiglio, Juan José, Holsboer, F., Arzt, E., Inda, C., Senin, S., Turck, C., Turck, C.W., Bonfiglio, J., Bonfiglio, J.J., Turck, Christoph W., Refojo, D., Giacomini, Damiana Paula   +21 more
core   +1 more source

Plasma amylin levels in migraine and after erenumab treatment: A REFORM study

Headache: The Journal of Head and Face Pain, EarlyView.
Plain Language Summary Researchers are searching for blood tests that can show what is happening in migraine and help predict who will benefit from preventive treatment, and blood amylin (a signaling molecule known to trigger migraine) has been shown to be elevated in people with chronic migraine.
Rogelio Domínguez‐Moreno, Tyla I. Alexander, William K. Karlsson, Haidar M. Al‐Khazali, Michael L. Garelja, Rune H. Christensen, Messoud Ashina, Debbie L. Hay, Håkan Ashina   +8 more
wiley   +1 more source

CRH-R1/2 vermittelte Effekte von Corticotropin-Releasing-Hormon (CRH) auf die Monozytenfunktion und Monozyten-Endothel-Interaktion [PDF]

, 2007
Neben den klassischen kardiovaskulären Risikofaktoren wie arterielle Hypertonie oder Hypercholesterinämie kommen den psychosozialen Faktoren wie Stress oder Depression eine entscheidene Rolle als Risikofaktor für die Entwicklung der Atherosklerose zu ...
Straube, Florian
core  

Impaired CRH and urocortin expression and function in eutopic endometrium of women with endometriosis

, 2011
Context: Women with endometriosis have altered endometrial function. CRH and urocortin (Ucn) are neuropeptides produced by human endometrium and modulate endometrial decidualization.
De Pascalis, F., Novembri, R., Flavio De Pascalis, Borges, L. E., Lavinia Estrela Borges, Pasquale Florio, Patrizia Carrarelli, Rocha, A. L., Felice Petraglia, Carrarelli, P., Petraglia, F., Florio, P., Romina Novembri, Ana Luiza Lunardi Rocha, Petraglia, Felice   +14 more
core   +1 more source

The role of the adenosinergic pathway in resistance to hypomethylating agents in patients with high‐risk myelodysplastic syndromes

British Journal of Haematology, EarlyView.
George Vrachiolias, Eleftheria Lamprianidou, Athanasios Tasis, Theodoros Spyropoulos, Despoina Dimitriou, Chryssa Kymparidou, Christina Misidou, Konstantinos Liapis, Emmanouil Spanoudakis, Maria Koffa, Menelaos Papoutselis, Iliana Stamatiou, Elsa Bernard, Elli Papaemmanuil, Ioannis Mitroulis, Ioannis Kotsianidis   +15 more
wiley   +1 more source

Modulation of sebocyte function in acne: A pathway‐inclusive review

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Acne is multifactorial, with the sebocyte acting as a central immunometabolic hub linking lipogenic, inflammatory, hormonal and barrier pathways. Mapping established and investigational therapies onto this sebocyte‐centred model offers a mechanism‐based framework that complements existing treatment paradigms and may guide more targeted, antibiotic ...
Christos C. Zouboulis, Apostolos Pappas, Katja Martin, Mauro Picardo   +3 more
wiley   +1 more source

Central Deficiency of Corticotropin-Releasing Hormone Receptor Type 1 (CRH-R1) Abolishes Effects of CRH on NREM But Not on REM Sleep in Mice

, 2010
Study Objectives: Corticotropin-releasing hormone (CRH) is the major activator of the hypothalamic-pituitary-adrenocortical (HPA) system and orchestrates the neuroendocrine, autonomous as well as behavioral responses to stress.
Wolfgang Wurst, Romanowski, C., Romanowski, C.P.N., Deussing, J., Wurst, W., Flachskamm, C., Kimura, M., Holsboer, F., Deussing, J.M., Thomas Fenzl, Florian Holsboer, Mayumi Kimura, Jan M. Deussing, Fenzl, T., Christoph PN Romanowski, Cornelia Flachskamm   +15 more
core   +1 more source

Microbiome and Metabolomics in Obesity: Advances in Understanding and Interventions Across the Lifespan

Obesity Reviews, EarlyView.
ABSTRACT Obesity arises from intertwined and reciprocal diet‐microbiome‐host pathways that reshape energy balance, insulin sensitivity, and inflammation. This review synthesizes mechanistic links between microbial functions and metabolic control, charts lifestyle‐related lifecourse dynamics from birth to older age, examines how GLP‐1‐based therapies ...
Ioanna Panagiota Kalafati, David Krongauz, Alice Bosco, Antonio Noto, Cristina Piras, Maria Kafyra, Angelica Dessì, Matteo Mauri, Luigi Atzori, Adina Weinberger, Vassilios Fanos, George V. Dedoussis, on behalf of the BETTER4U consortium   +12 more
wiley   +1 more source

Neurotensin and CRH interactions augment human mast cell activation.

, 2012
Stress affects immunity, but the mechanism is not known. Neurotensin (NT) and corticotropin-releasing hormone (CRH) are secreted under stress in various tissues, and have immunomodulatory actions.
Asimenia Angelidou, Bodi Zhang, Nikolaos Sismanopoulos, Theoharis C Theoharides, Konstantinos–Dionysios Alysandratos (120488), Shahrzad Asadi (109984), Shahrzad Asadi, Konstantinos-Dionysios Alysandratos, Hailing Yang (120494), Agatha Critchfield, Hailing Yang, Asimenia Angelidou (120491), Nikolaos Sismanopoulos (109992), Agatha Critchfield (120496), Bodi Zhang (109980), Theoharis C. Theoharides (109996)   +15 more
core   +1 more source

Unravelling Mechanisms of Acquired Drought Tolerance by Priming in Tomato Using Integrative Multi‐Omics Phenotypic Analysis

Plant Biotechnology Journal, EarlyView.
ABSTRACT The escalating frequency and intensity of recent droughts threaten global crop production and food security. Although drought priming is crucial for plant drought resilience, the mechanisms imparting drought stress memory remain poorly understood, especially in crops such as tomato. This study elucidates the mechanisms of drought stress memory
Rong Zhou, Yankai Li, Ge Wang, Hong Chen, Xiaqing Yu, Yinlei Wang, Xuedong Yang, Zhen Lyu, Trupti Joshi, Xiaoming Song, Carl‐Otto Ottosen, Ian Charles Dodd, Ron Mittler, Fangling Jiang, Zhen Wu   +14 more
wiley   +1 more source