Results 111 to 120 of about 83,953 (231)

Early adversity and the comorbidity between metabolic disease and psychopathology

The Journal of Physiology, EarlyView.
Abstract figure legend Hierarchical diagram representing the interplay between the genetic background and early life adversities and its effect on multiple physiological processes that ultimately impact on the risk for the comorbdity between psychopathology and cardiometabolic disorders.
Ameyalli Gómez‐Ilescas, Patricia Pelufo Silveira   +1 more
wiley   +1 more source

Neuropeptide-mediated excitability: a key triggering mechanism for seizure generation in the developing brain. [PDF]

, 1998
Most human seizures occur early in life,consistent with established excitability-promoting features of the developing brain. Surprisingly, the majority of developmental seizures are not spontaneous but are provoked by injurious or stressful stimuli. What
Baram, TZ, Hatalski, CG
core  

Intramuscular pathways of maladaptation in overtraining syndrome

The Journal of Physiology, EarlyView.
Abstract figure legend The transition from adaptive overreaching to maladaptive overtraining and mechanisms through which excessive training load can lead to performance decline. Four interconnected pathophysiological domains are highlighted: neural fatigue, involving both central and peripheral components such as altered sensory feedback and reflex ...
Emily Shorter, Oscar Horwath, Sabrina Tzivia Barsky, Ferdinand von Walden, Johanna T. Lanner   +4 more
wiley   +1 more source

Untersuchung des CRH/CRH-Rezeptor Systems mit Hilfe Zelltyp-spezifisch CRH-überexprimierender Mauslinien [PDF]

, 2010
Das Neuropeptid Corticotropin-Releasing-Hormone (CRH) spielt sowohl als Hormon als auch als Neuromodulator eine wichtige Rolle im Rahmen der physiologischen Stressantwort. Klinische Studien und Tierexperimente legen nahe, dass eine Dysregulationen des CRH-Systems an der Entstehung und Manifestierung psychischer Erkrankungen wie Angststörungen oder ...
openaire  

Kisspeptin as a test of hypothalamic dysfunction in pubertal and reproductive disorders

Andrology, Volume 14, Issue 4, Page 1002-1016, May 2026.
Abstract The hypothalamic–pituitary–gonadal axis is regulated by the gonadotropin‐releasing hormone pulse generator in the hypothalamus. This is comprised of neurons that secrete kisspeptin in a pulsatile manner to stimulate the release of GnRH, and, in turn, downstream gonadotropins from the pituitary gland, and subsequently sex steroids and ...
Aureliane C. S. Pierret, Aaran H. Patel, Elisabeth Daniels, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara   +5 more
wiley   +1 more source

Infantile spasms: hypothesis-driven therapy and pilot human infant experiments using corticotropin-releasing hormone receptor antagonists. [PDF]

, 1999
Background and rationaleInfantile spasms (IS) are an age-specific seizure disorder occurring in 1:2,000 infants and associated with mental retardation in approximately 90% of affected individuals. The costs of IS in terms of loss of lifetime productivity
Baram, TZ, Brunson, K, Haden, E, Mitchell, WG   +3 more
core  

Cortisol Stability at 16 and 30 Years in Urine Specimens Stored at −20°C

American Journal of Human Biology, Volume 38, Issue 4, April 2026.
ABSTRACT Objective This study aims to investigate whether urinary cortisol can be reliably measured after long‐term storage at −20°C, using urine samples collected in 1993 from rural Bangladeshi women, and assayed after 16 and 30 years (2009 and 2023). Methods Specimens were collected by participants, placed in coolers with ice packs, transported to a ...
Anwesha Pan, Madison Saunders, Darryl J. Holman   +2 more
wiley   +1 more source

Assessing Conflict Potential Between Birds and Small‐Scale Fisheries in Lake Titicaca

Aquatic Conservation: Marine and Freshwater Ecosystems, Volume 36, Issue 4, April 2026.
ABSTRACT Globally, fisheries bycatch constitutes a threat to aquatic birds. However, while the threat is global, the threat from bycatch in inland fisheries, and from artisanal or small‐scale fishing, is particularly understudied. Here, we present the first attempt to map the vulnerability of birds to fisheries bycatch, and the conflict potential ...
D. A. Villar, Paola Velásquez‐Noriega, Bastian Thomsen, Edwin R. Gutiérrez Tito, Anahi Cosky Paca‐Condori, Edmundo G. Moreno Terrazas, Ronald Hinojosa Cárdenas, Alfredo Balcón Cuno, Carmen Villanueva, Patrick Chapman, Jhazel Quispe, Andrew G. Gosler   +11 more
wiley   +1 more source

Role of CRH in colitis and colitis-associated cancer: a combinative result of central and peripheral effects?

Frontiers in Endocrinology
Corticotropin-releasing factor family peptides (CRF peptides) comprise corticotropin releasing hormone (CRH), urocortin (UCN1), UCN2 and UCN3. CRH is first isolated in the brain and later with UCNs found in many peripheral cells/tissues including the ...
Chao Zhu, Shengnan Li
doaj   +1 more source

Electroconvulsive Therapy in Schizophrenia: Exploratory Study on the Efficacy, Cognitive Effects, and Safety of Right Unilateral Versus Bitemporal Techniques

Brain and Behavior, Volume 16, Issue 4, April 2026.
The purpose of the study was to compare the effectiveness, safety, and cognitive effects of BTS versus RUS in hospitalized patients with schizophrenia. The results should be considered preliminary due to the sample size (n = 17) and lack of blinding of participants.
Héctor O. Castañeda‐González, Alexandra Magaña‐Ornelas, Aurea Ruby Santiago‐Maury, Sophia Sánchez López, Iván de Jesús Leonor‐Hernández, Hector Cabello‐Rangel   +5 more
wiley   +1 more source