Results 111 to 120 of about 48,713 (266)

Intramuscular pathways of maladaptation in overtraining syndrome

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend The transition from adaptive overreaching to maladaptive overtraining and mechanisms through which excessive training load can lead to performance decline. Four interconnected pathophysiological domains are highlighted: neural fatigue, involving both central and peripheral components such as altered sensory feedback and reflex ...
Emily Shorter   +4 more
wiley   +1 more source

Olutasidenib Alone or in Combination With Azacitidine as a Bridge to Transplant in Relapsed/Refractory mIDH1 AML

open access: yes
European Journal of Haematology, EarlyView.
Shira N. Dinner   +16 more
wiley   +1 more source

Single-cell transcriptomics reveals transcriptional reprogramming and microenvironmental remodeling in ectopic ACTH/CRH-secreting pheochromocytomas

open access: yesJournal of Translational Medicine
Background Ectopic ACTH- and/or CRH-secreting pheochromocytomas (ACTH+CRH+PCCs) are rare tumors that can mimic Cushing’s syndrome and complicate the diagnosis and treatment clinically.
Wan Su   +14 more
doaj   +1 more source

IL-6 and TGF-β1 production from Crh+/+ and Crh−/− fibroblasts.

open access: yes, 2013
Primary dermal fibroblasts isolated from Crh+/+ and Crh−/− mice were cultured in 24-well plates (105 cells/well). Supernatants were collected and analyzed by ELISA for IL-6 (a) or TGF-β1 (b).
Maria Venihaki (348138)   +8 more
core   +1 more source

Healthcare Waste Generation Rates in the Three Categories of Public Healthcare Facilities in Malawi

open access: yesPublic Health Challenges, Volume 5, Issue 4, December 2026.
Two tertiary (Kamuzu and Mzuzu Central), secondary (Nkhata Bay and Rumphi), and primary (Bolero and Chintheche Rural) healthcare institutions participated in a study on healthcare waste. Waste was categorized as nonhazardous or hazardous. Significant differences in waste generation rates were observed on the basis of facility type (p < 0.001). ABSTRACT
Grace O. Ogbonna   +5 more
wiley   +1 more source

Genetic dissection of CRH-controlled neurocircuitries of stress.

open access: yes, 2015
Dysregulated corticotropin-releasing hormone (CRH)-circuits have been implicated in the pathophysiology of stress-related psychiatric disorders. This study provides novel insights into the underlying CRH-neurotransmitter interactions.
Dedic, N.
core  

Improving String Matching through Enhanced Hashing

open access: yesSoftware: Practice and Experience, Volume 56, Issue 11, Page 1323-1333, November 2026.
ABSTRACT Background Hashing offers opportunities to tune string matching algorithms while enabling efficient data retrieval and pattern detection. Many of the best algorithms apply hashing. Objective We try to develop faster online algorithms for exact string matching.
Francesco Pio Marino, Jorma Tarhio
wiley   +1 more source

Novel functional roles for CRH -binding protein at the pituitary.

open access: yes, 2003
Corticotropin-releasing hormone (CRH) is the key regulator of the mammalian stress response. The bioactivity of CRH and other CRH-like peptides is modulated by the CRH-binding protein (CRH-BP), a secreted glycoprotein that is expressed at multiple sites ...
Speert, Debra Beth
core  

KRAS Mutations Predict Inferior Post‐Remission Outcomes in Newly Diagnosed Acute Myeloid Leukemia With MAPK Pathway Mutations

open access: yesEuropean Journal of Haematology, Volume 117, Issue 5, Page 1318-1326, November 2026.
ABSTRACT Somatic mutations in the MAPK signaling pathway are frequently identified at AML diagnosis; however, their impact on treatment resistance and long‐term survival remains unclear. We conducted a retrospective study of patients with newly diagnosed MAPK‐mutated AML seen at the University of Iowa Health Care.
Kensuke Takaoka   +6 more
wiley   +1 more source

Dissecting the role of CRH and CRH-R1 in Alzheimer´s disease.

open access: yes, 2012
In Alzheimer´s Disesase (AD) alterations of the corticotropin-releasing hormone (CRH) system and a hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis have been reported. To shed light on the involvement of CRH and its receptor CRH-R1 in
Lerche, K.
core  

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