Results 221 to 230 of about 48,713 (266)
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CRH and the immune system

Journal of Neuroimmunology, 1997
Inflammatory cytokines released during immune system activation can stimulate the hypothalamic-pituitary-adrenal axis and cause increased secretion of corticotropin-releasing hormone (CRH), adrenocorticotropin and glucocorticoids. Identification of CRH peptide and mRNA, as well as its receptors in immune tissues, suggested a role for this peptide as a ...
K, Karalis   +4 more
openaire   +2 more sources

Functional characteristics of CRH receptors and potential clinical applications of CRH-receptor antagonists

Trends in Endocrinology and Metabolism, 2002
Corticotropin-releasing hormone (CRH) plays a major role in coordinating the behavioral, endocrine, autonomic and immune responses to stress. CRH and CRH-related peptides and their receptors are present in the central nervous system and in a wide variety of peripheral tissues, including the immune, cardiovascular and reproductive systems, and have been
Georgios P. Chrousos   +1 more
exaly   +3 more sources

Cholinergic modulation of CRH and non-CRH neurons in Barrington’s nucleus of the mouse

Journal of Neurophysiology, 2020
This study investigates the effects of bath-applied cholinergic agonists on Barrington’s nucleus (BarN) neurons in vitro. They were either excitatory, through nicotinic receptors, or inhibitory, through muscarinic receptors. Putative corticotropin-releasing hormone (CRH)-expressing neurons in BarN, as well as putative non-CRH-expressing neurons ...
Masahiro Kawatani   +5 more
openaire   +2 more sources

CRH-Stimulation of Cyclic Adenosine 5'-Monophosphate Pathway Is Partially Inhibited by the Coexpression of CRH-R1 and CRH-R2α

Endocrine, 2005
Corticotropin-releasing hormone (CRH) is one of the major proteins responsible for brain stress regulation. Two well-known receptors have been described: type 1 and type 2alpha, both members of the receptor superfamily of G protein-coupled receptors (GPCR).
G, Maya-Núñez   +2 more
openaire   +2 more sources

Corticotrophin-releasing hormone (CRH)-binding protein interference with CRH antibody binding: implications for direct CRH immunoassay

Journal of Endocrinology, 1995
Abstract Direct immunoassay of plasma corticotrophin-releasing hormone (CRH) is potentially subject to interference from high levels of CRH-binding protein (CRH-BP) that exist in the human circulation. In this study, we tested the effect of CRH-free, native CRH-BP (6·4 nmol/l) purified from human plasma, CRH-BP diluent alone, normal ...
E A, Linton   +7 more
openaire   +2 more sources

CRH and α-helical-CRH modulate behavioral measures of arousal in monkeys

Pharmacology Biochemistry and Behavior, 1989
Several neuropeptides involved in the control of pituitary-adrenal activation have also been shown to have behavioral effects which may be mediated by actions on brain mechanisms independent of pituitary release. The behavioral effects of intraventricular administration of CRH and the synthetic peptide antagonist alpha-helical-CRH were assessed in ...
J T, Winslow, J D, Newman, T R, Insel
openaire   +2 more sources

Cutaneous Expression of CRH and CRH‐R: Is There a “Skin Stress Response System?”

Annals of the New York Academy of Sciences, 1999
ABSTRACT:The classical neuroendocrine pathway for response to systemic stress is by hypothalamic release of corticotropin releasing hormone (CRH), subsequent activation of pituitary CRH receptors (CRH‐R), and production and release of proopiomelanocortin (POMC) derived peptides.
A T, Slominski   +13 more
openaire   +2 more sources

The Peripheral CRH/Urocortin System

Annals of the New York Academy of Sciences, 2000
Abstract:The hypothalmus‐pituitary‐adrenal (HPA) axis and the immune system communicate at multiple levels: On the one hand, immune system‐derived substances, such as interleukin‐1, interleukin‐6, tumor necrosis factor alpha, and leukemia inhibitory factor can stimulate the HPA axis.
C M, Bamberger, A M, Bamberger
openaire   +2 more sources

Brake Distance Calculation of CRH

Applied Mechanics and Materials, 2012
With the development of high-speed railway in China, CRH is widely used in railway transportation. Traditional method of braking distance calculation is not suitable for CRH. In this paper, a more accurate brake distance of CRH locomotive has been calculated by using the calculus form of the kinematics formulas and verified by real data.
null Xu Peng   +3 more
openaire   +1 more source

Animal Models of CRH Deficiency

Frontiers in Neuroendocrinology, 1999
Corticotropin-releasing hormone (CRH), the major regulator of hypothalamic-pituitary-adrenal (HPA) axis, was first isolated due to its ability to stimulate the release of adrenocorticotropic hormone from the anterior pituitary. Later, it was also found to have also a wide spectrum of actions within the central nervous system and the periphery.
M, Venihaki, J A, Majzoub
openaire   +2 more sources

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