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Reproduction under Siege: How Chronic Stress Hijacks the HPG Axis?
NeuroendocrinologyXu D, Zhao X, Chen W, Liu Y, Wang C.
europepmc +1 more source
Current Molecular Pharmacology, 2017 The Corticotropin-releasing Hormone (CRH) mammalian family members include CRH, urocortin I, Stresscopin (SCP) and Stresscopin-related peptide (SRP), along with the CRH receptors type 1 (CRHR1) and type 2 (CRHR2), and CRH-binding protein (CRH-BP). These family members differ in their tissue distribution and pharmacology.
Georgios P. Chrousos
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Journal of Reproductive Immunology, 2011
Capacity to cope with stress is crucial for survival and also reproduction. The stress response differs in the various parts of an organism. Central corticotropin-releasing hormone (CRH) has been identified to be the main stress regulator. In the reproductive system, stress has a deleterious effect on reproduction and CRH is associated with dysfunction
Júlia Szekeres-Barthó +2 more
exaly +3 more sources
Capacity to cope with stress is crucial for survival and also reproduction. The stress response differs in the various parts of an organism. Central corticotropin-releasing hormone (CRH) has been identified to be the main stress regulator. In the reproductive system, stress has a deleterious effect on reproduction and CRH is associated with dysfunction
Júlia Szekeres-Barthó +2 more
exaly +3 more sources
Cutaneous expression of corticotropin-releasing hormone (CRH), urocortin, and CRH receptors.
FASEB Journal, 2001ABSTRACT Studies in mammalian skin have shown expression of the genes for corticotropin‐releasing hormone (CRH) and the related urocortin peptide, with subsequent production of the respective peptides. Recent molecular and biochemical analyses have further revealed the presence of CRH receptors (CRH‐Rs). These CRH‐
Alexander N. Pisarchik +1 more
exaly +3 more sources
The molecular physiology of CRH neurons [PDF]
Frontiers in Neuroendocrinology, 2012 Corticotropin releasing hormone (CRH) is essential for stress adaptation by mediating hypothalamic-pituitary-adrenal (HPA) axis, behavioral and autonomic responses to stress. Activation of CRH neurons depends on neural afferents from the brain stem and limbic system, leading to sequential CRH release and synthesis.
Greti Aguilera
exaly +3 more sources
Experimental and Clinical Endocrinology & Diabetes, 2003
Recent research suggests a significant role for placental corticotropin-releasing hormone (CRH) in controlling human parturition. This paper describes the expression of CRH, CRH receptors 1 and 2, and CRH binding protein (CRH-BP) in gestational tissue in late pregnancy.
Wetzka, Birgit +7 more
openaire +3 more sources
Recent research suggests a significant role for placental corticotropin-releasing hormone (CRH) in controlling human parturition. This paper describes the expression of CRH, CRH receptors 1 and 2, and CRH binding protein (CRH-BP) in gestational tissue in late pregnancy.
Wetzka, Birgit +7 more
openaire +3 more sources