Results 101 to 110 of about 9,312 (218)

Discovery of a Baloxavir‐Inspired Endonuclease Inhibitor That Prevents Herpes Simplex Virus 1 Replication in Cell Culture and In Vivo

Advanced Science, Volume 12, Issue 42, November 13, 2025.
Current herpesvirus treatments targeting the viral DNA polymerase are limited by toxicities and drug resistance. Novel compounds inhibiting the nuclease activity of the herpes simplex virus 1 (HSV‐1) terminase complex, required for viral genome packaging, have been identified.
Sabina Andreu, Kai Tang, Jiahui Zhou, Gabriel Pino‐Peco, Nerea López‐Carrobles, Raquel Bello‐Morales, Daniel Galdo‐Torres, Lina Zhang, Federico Gago, José Antonio López‐Guerrero, Xinyong Liu, Peng Zhan, Luis Menéndez‐Arias   +12 more
wiley   +1 more source

Looking Beyond the Lens of Crimean-Congo Hemorrhagic Fever in Africa

Emerging Infectious Diseases
Crimean-Congo hemorrhagic fever (CCHF) is a lethal viral disease that has severe public health effects throughout Africa and a case fatality rate of 10%–40%.
Olalekan John Okesanya, Gbolahan Deji Olatunji, Emmanuel Kokori, Noah Olabode Olaleke, Olaniyi Abideen Adigun, Emery Manirambona, Don Eliseo Lucero-Prisno   +6 more
doaj   +1 more source

Acute Hepatic Failure in Crimean‐Congo Hemorrhagic Fever: A Case Report

Clinical Case Reports, Volume 13, Issue 11, November 2025.
ABSTRACT Acute hepatic failure is a rare but critical complication of Crimean‐Congo hemorrhagic fever (CCHF). This case presents acute hepatic failure with liver enzyme elevation and thrombocytopenia. The patient responded well to treatment that included ribavirin, lactulose, rifaximin, and supportive therapies.
Ahmed Abdulhussain Shahatta, Sajjad Ghanim Al‐Badri, Khadija Naeem, Abdulrahman Khaldoon Hamid, Nabeel Al‐Fatlawi, Ali Saad Al‐Shammari, Sabry Babiker H. Sayed, Abbas Hamza Abbas, Ali Azeez Shlaka   +8 more
wiley   +1 more source

Tick‐Borne Viruses in Finland: Public Health Risks, Interventions and Research Insights

Veterinary Medicine and Science, Volume 11, Issue 6, November 2025.
ABSTRACT Ticks are obligate haematophagous arthropods that serve as vectors for diverse pathogens, including viruses, bacteria and protozoa. In Finland, the two primary tick species, Ixodes ricinus (castor bean tick) and Ixodes persulcatus (taiga tick), have been identified in the transmission of tick‐borne viruses (TBV), notably tick‐borne ...
Theophilus Yaw Alale, Tero Klemola, Jani J. Sormunen, Heli Harvala, Laura Kakkola, Jessica Tikkala, Eero J. Vesterinen   +6 more
wiley   +1 more source

Interferon-stimulated gene (ISG)-expression screening reveals the specific antibunyaviral activity of ISG20 [PDF]

, 2018
Bunyaviruses pose a significant threat to human health, prosperity and food security. In response to viral infections, interferons (IFNs) upregulate the expression of hundreds of interferon stimulated genes (ISGs) whose cumulative action can potently ...
Bieniasz, Paul D., Brennan, Benjamin, Elliott, Richard M., Feng, Junjie, Koudriakova, Elina, Kreher, Felix, Rezelj, Veronica V., Rice, Charles M., Rihn, Suzannah J., Shaw, Andrew E., Shi, Xiaohong, Slack, Gillian S., Tilston-Lunel, Natasha L., Turnbull, Matthew L., Wickenhagen, Arthur, Wilson, Sam J.   +15 more
core   +1 more source

Crimean-Congo Hemorrhagic Fever Virus in Ticks, Southwestern Europe, 2010

Emerging Infectious Diseases, 2012
To the Editor: Crimean-Congo hemorrhagic fever virus (CCHFV; family Bunyaviridae, genus Nairovirus) causes outbreaks of severe hemorrhagic fever in humans, with case-fatality rates
Estrada-Peña, Agustín, Palomar, Ana M., Santibáñez, Paula, Sánchez, Nely, Habela, Miguel A., Portillo, Aránzazu, Romero, Lourdes, Oteo, José A.   +7 more
openaire   +5 more sources

Bayesian Phylogeography of Crimean-Congo Hemorrhagic Fever Virus in Europe

PLoS ONE, 2013
Crimean-Congo hemorrhagic fever (CCHF) is a zoonosis mainly transmitted by ticks that causes severe hemorrhagic fever and has a mortality rate of 5-60%. The first outbreak of CCHF occurred in the Crimean peninsula in 1944-45 and it has recently emerged in the Balkans and eastern Mediterranean.
G. Zehender, E. Ebranati, R. Shkjezi, A. Papa, C. Luzzago, E. Gabanelli, A. Lo Presti, A. Lai, G. Rezza, M. Galli, S. Bino, M. Ciccozzi   +11 more
openaire   +6 more sources

Newly recognized mosquito-associated viruses in mainland China, in the last two decades

Virology Journal, 2011
There are four principal arboviruses in mainland China. Two kinds of them are mosquito-borne viruses, namely Japanese encephalitis virus and dengue virus, which lead to Japanese encephalitis, and dengue fever/dengue hemorrhagic fever respectively; the ...
Liang Guodong, Gao Xiaoyan, Liu Hong
doaj   +1 more source

Pathways for entry of livestock arboviruses into Great Britain : assessing the strength of evidence [PDF]

, 2015
The emergence of bluetongue virus and Schmallenberg virus in Great Britain (GB) during the last decade has highlighted the need for understanding the relative importance of the various pathways of the entry of livestock arboviruses so as to help focus ...
Gale, P., Kelly, Louise, Snary, E.L.
core   +1 more source

Schmallenberg virus: emergence of an Orthobunyavirus among ruminants in Western Europe [PDF]

, 2012
Recently, a novel virus has been identified among ruminants in Western Europe. This virus, the so-called Schmallenberg virus, belongs to the family Bunyaviridae, genus Orthobunyavirus, serogroup Simbu and is closely related to Akabane, Aino and Shamonda ...
Bertels, Guido, Cay, Ann Brigitte, Nauwynck, Hans, Steukers, Lennert   +3 more
core