Results 101 to 110 of about 119,569 (285)

Crisis Intervention Psychotherapy in the Age of COVID-19. [PDF]

J Psychiatr Pract, 2021
Feinstein RE.
europepmc   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Evaluation of Ongoing Crisis Intervention Team (CIT) Training for Law Enforcement Using the ECHO Model. [PDF]

J Police Crim Psychol, 2022
Crisanti AS, Fairfax-Columbo J, Duran D, Rosenbaum NA, Melendrez B, Trujillo I, Earheart JA, Tinney M.   +7 more
europepmc   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Longitudinal associations between peer rejection, fear of negative evaluation and depressive symptoms in Chinese adolescents: a cross-lagged panel analysis

BMC Psychology
Background While peer rejection and depressive symptoms are robustly linked in adolescents, their directional relationships and underlying mechanisms remain unclear, especially in Chinese cultural contexts and mid- to late adolescence.
Yuelin Chen, Zihan Xie, Ying Yang
doaj   +1 more source

Cooperation of the School With the Family and the Local Community – Selected Aspects

Horyzonty Wychowania
RESEARCH OBJECTIVE: The article describes the conditions, assumptions and benefits regarding the process of cooperation of the school with the family and the local community in the context of selected educational aspects.
Anna Błasiak, Sylwia Michalec-Jękot
doaj   +1 more source

Crisis Intervention Team (CIT) training and impact on mental illness and substance use-related stigma among law enforcement. [PDF]

Drug Alcohol Depend Rep, 2022
Nick GA, Williams S, Lekas HM, Pahl K, Blau C, Kamin D, Fuller-Lewis C.   +6 more
europepmc   +1 more source

Comparative efficacy of multiple psychological interventions for psychological crisis in people affected by COVID-19：a bayesian network meta-analysis [PDF]

, 2020
Yang Yang, Yimin Zhang, Shaowen Hu, Chunzhi Tang, Haibo Lin   +4 more
openalex   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source