Results 91 to 100 of about 1,834,114 (325)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Problems of Ensuring the Efficiency of the Public Crisis Management
Управленческие науки, 2019 The success of strategic and tactical problems solution of the socio-economic development of the Russian Federation in much depends on efficiency of the public crisis management which is one of the most difficult spheres of regulation as has to possess ...
A. N. Ryakhovskaya
doaj +1 more source
MANAGEMENT AND RESCUE FROM CRISIS [PDF]
Management is the primary factor for overall amplification of efficiency, effectiveness and competitiveness of the companies and economy. In this context, is significant to highlight promotion of strategic management, managerial reengineering, improving ...
Ion Verboncu
core
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Стратегические решения и риск-менеджмент, 2015 The article analyses problems of self-regulating organizations of insolvency officers’ and insolvency officers’ activities on the current stage of economic growth.
N. G. Akulova, S. O. Voronkov
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Assessment of the Added-Value of Sentinel-2 for Detecting Built-up Areas
Remote Sensing, 2016 Monitoring of the human-induced changes and the availability of reliable and methodologically consistent urban area maps are essential to support sustainable urban development on a global scale.
Martino Pesaresi +5 more
doaj +1 more source
979 One-stop crisis management centres (OCMCs): a sanctuary for survivors of violence [PDF]
, 2016 Rekha Rana
openalex +1 more source