Results 101 to 110 of about 9,718,287 (381)

EGFR‐STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1‐positive prostate cancer

Molecular Oncology, EarlyView.
Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva, Bernardo Orr, Ana Azeredo, Andreia Brandão, Manuel R. Teixeira, Paula Paulo   +5 more
wiley   +1 more source

Taming Deep Uncertainty: The Potential of Pragmatist Principles for Understanding and Improving Strategic Crisis Management

, 2019
Modern societies are increasingly faced with “unknown unknowns,” Black Swans, and mega-crises. Both public and corporate leaders find it deeply challenging to respond to these crisis events.
C. Ansell, A. Boin
semanticscholar   +1 more source

MODELING THE PROCESS OF APPLYING ANTI-CRISIS MANAGEMENT IN THE SYSTEM OF ENSURING FINANCIAL SECURITY OF THE ENTERPRISE

Business: Theory and Practice, 2019
The methodological approach to the application of anti-crisis management in the system of ensuring financial security of the enterprise, unlike the existing ones, summarizes and systematizes the theoretical and methodological features of determining the ...
O. Sylkin, M. Kryshtanovych, A. Zachepa, S. Bilous, A. Krasko   +4 more
semanticscholar   +1 more source

Evaluation and modification of tumor cell isolation techniques from malignant effusions for rapid drug sensitivity testing

Molecular Oncology, EarlyView.
Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...
Navit Mooshayef, Hana Barhom, Sumit Chatterji, Netta Hecht, Oran Warhaftig, Iris Kamer, Oranit Zadok, Jair Bar, Limor Broday, Amir Onn, Michael Peled   +10 more
wiley   +1 more source

Complex Automated Information System for Remote Management of Crisis Situations in Rail Transport

Communications, 2013
The paper deals with topical information from the area of crisis information support. The contributing authors work at three co-operating universities where the subject of transport support in crises is tackled.
Zdenek Dvorak, Maria Luskova, Petr Hruza, Radovan Sousek   +3 more
doaj   +1 more source

Crisis management research (1985–2020) in the hospitality and tourism industry: A review and research agenda

Tourism Management, 2021
T. Wut, J. Xu, S. Wong
semanticscholar   +1 more source

Prepared for a crisis? Basic elements of crisis management in an organisation

Economic Research-Ekonomska Istraživanja, 2019
The aim of this paper is to identify the basic elements that must be taken into account when constituting the complete process of crisis management in an organisation.
M. Mikušová, P. Horváthová
semanticscholar   +1 more source

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

Molecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan, Moshe Leitner, Amos Toren, Shoshana Paglin, Michal Yalon   +4 more
wiley   +1 more source

Comprehensive profiling of lncRNAs and mRNAs enriched in small extracellular vesicles for early noninvasive detection of colorectal cancer: diagnostic panel assembly and extensive validation

Molecular Oncology, EarlyView.
Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova, Marketa Pavlikova, Lucie Pifkova, Robin Jugas, Tana Machackova, Lenka Radova, Milana Sachlova, Renata Bartosova, Tetiana Samoilenko, Zuzana Feckova, Jana Orlickova, Erika Slamova, Elleni Ponechal Michu, Dagmar Al Tukmachi, Michaela Ruckova, Martina Vodinska, Jan Kotoucek, Tina Catela Ivkovic, Marie Boudna, Lucia Bohovicova, Teodor Stanek, Jana Halamkova, Martin Svoboda, Vladimir Prochazka, Tomas Grolich, Zdenek Kala, Ondrej Slaby   +26 more
wiley   +1 more source

Assessment of the Added-Value of Sentinel-2 for Detecting Built-up Areas

Remote Sensing, 2016
Monitoring of the human-induced changes and the availability of reliable and methodologically consistent urban area maps are essential to support sustainable urban development on a global scale.
Martino Pesaresi, Christina Corbane, Andreea Julea, Aneta J. Florczyk, Vasileios Syrris, Pierre Soille   +5 more
doaj   +1 more source