Results 181 to 190 of about 1,254,871 (374)
Advanced Science, EarlyView.Phosphorylation of Optineurin by TBK1 induces the formation of filaments that condensate upon binding to linear polyubiquitin. Membrane‐anchored LC3 partitions into these condensates, suggesting that phase separation of filamentous Optineurin with ubiquitylated cargo promotes the sequestration of cargo and its subsequent alignment with LC3‐positive ...
Maria G. Herrera +10 more
wiley +1 more source
Comprehensive Analysis of CRISPR-Cas Systems and Their Influence on Antibiotic Resistance in Strains
Bioinformatics and Biology InsightsSalmonella enterica is a gram-negative bacterium that demonstrates a remarkable ability to acquire antibiotic resistance genes (ARGs). The role of the CRISPR-Cas system in influencing antibiotic resistance in S.
Tina Fallah, Morvarid Shafiei
doaj +1 more source
CRISPR-Cas off-target detection using Oxford Nanopore sequencing - is the mitochondrial genome more vulnerable to off-targets? [PDF]
, 2019 Sandeep Chakraborty
openalex +1 more source
EXTH-37. TARGETING THE IDH1R132H MUTATION IN GLIOMAS BY CRISPR-CAS PRECISION BASE EDITING [PDF]
, 2022 Remi Weber +7 more
openalex +1 more source
An updated evolutionary classification of CRISPR–Cas systems
Nature Reviews Microbiology, 2015 K. Makarova +20 more
semanticscholar +1 more source
Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3
Advanced Science, EarlyView.In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang +16 more
wiley +1 more source
CcpA and CodY Regulate CRISPR-Cas System of Streptococcus mutans
, 2023 Dayoung Kang, Andy Kim, Jeong Nam Kim
openalex +1 more source
Evolutionary classification of CRISPR–Cas systems: a burst of class 2 and derived variants
Nature Reviews Microbiology, 2019 K. Makarova +25 more
semanticscholar +1 more source
CD168 Identifies Proliferating Pancreatic Islet Cells in Murine and Human
Advanced Science, EarlyView.This study identifies CD168 as a conserved surface marker for proliferating β‐cells in mouse, human islets, and pancreatic islet tumors. CD168⁺ cells show high proliferation and low insulin expression. CD168+ cells form mostly uni‐β lineage clones, and some of the clones are multi‐lineage.
Shubo Yuan +21 more
wiley +1 more source