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Journal of Cellular Physiology, 2020
AbstractClustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR‐associated enzyme (Cas) is a naturally occurring genome editing tool adopted from the prokaryotic adaptive immune defense system. Currently, CRISPR/Cas9‐based genome editing has been becoming one of the most promising tools for treating human genetic diseases, including ...
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AbstractClustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR‐associated enzyme (Cas) is a naturally occurring genome editing tool adopted from the prokaryotic adaptive immune defense system. Currently, CRISPR/Cas9‐based genome editing has been becoming one of the most promising tools for treating human genetic diseases, including ...
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MicroRNA Detection with CRISPR/Cas
2023Low-cost detection of miRNAs has caught broad attention in recent years due to the potential application of these small noncoding RNAs for diagnostics and therapeutic purposes. Their small size and low abundance, however, derive challenges in engineering robust detection tools.
Xinyuan, Qiu +3 more
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Analysis & Sensing, 2022
AbstractCRISPR/Cas system is to be a powerful tool to construct the nucleic acid diagnostic platform. Specific recognition and cleavage of CRISPR/Cas systems enable selective recognition of analytes and physicochemical signal translation of biorecognition events.
Mengying Deng +3 more
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AbstractCRISPR/Cas system is to be a powerful tool to construct the nucleic acid diagnostic platform. Specific recognition and cleavage of CRISPR/Cas systems enable selective recognition of analytes and physicochemical signal translation of biorecognition events.
Mengying Deng +3 more
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CRISPR-Cas immunity in prokaryotes
Nature, 2015Prokaryotic organisms are threatened by a large array of viruses and have developed numerous defence strategies. Among these, only clustered, regularly interspaced short palindromic repeat (CRISPR)-Cas systems provide adaptive immunity against foreign elements. Upon viral injection, a small sequence of the viral genome, known as a spacer, is integrated
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CRISPR/Cas Powered Multiplexed Biosensing
Trends in Biotechnology, 2019Multiplexed CRISPR/Cas biosensing offers various possibilities for diagnosing different diseases by analyzing many analytes from one single specimen. However, in this relatively new field, nearly no multiplexing approaches exist, as many challenges need to be addressed.
Bruch, Richard +2 more
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CRISPR–Cas impedes archaeal mating
Nature Microbiology, 2018The early identification of repetitive genomic loci in Haloferax species was instrumental in igniting interest in CRISPR–Cas systems. Now, work in this genus has revealed an important role of CRISPR–Cas in reducing an unusual form of inter-species archaeal mating that occurs by cell fusion.
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Nature Reviews Molecular Cell Biology, 2019
CRISPR–Cas9-based prime editing supports the correction of a wide range of mutations, including transversions and insertions and deletions.
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CRISPR–Cas9-based prime editing supports the correction of a wide range of mutations, including transversions and insertions and deletions.
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2013
Discovery and seminal developments in the CRISPR field.- Occurrence, diversity of CRISPR-Cas systems and genotyping implications.- Evolution and classification of CRISPR-Cas systems and Cas protein families.- Regulation of CRISPR-based immune responses.- crRNA Biogenesis.- Distribution and mechanism of the Type I CRISPR/Cas Systems.- Type II ...
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Discovery and seminal developments in the CRISPR field.- Occurrence, diversity of CRISPR-Cas systems and genotyping implications.- Evolution and classification of CRISPR-Cas systems and Cas protein families.- Regulation of CRISPR-based immune responses.- crRNA Biogenesis.- Distribution and mechanism of the Type I CRISPR/Cas Systems.- Type II ...
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2021
The Nobel Prize in Chemistry in 2020 was awarded to two researchers in the field of molecular biology: French Emmanuelle Charpentier, who currently heads the Max Planck Unit for the Science of Pathogens (Berlin, Germany), and American Jennifer Doudna of the University of California (Berkeley, CA, USA) ???for the development of a method for genome ...
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The Nobel Prize in Chemistry in 2020 was awarded to two researchers in the field of molecular biology: French Emmanuelle Charpentier, who currently heads the Max Planck Unit for the Science of Pathogens (Berlin, Germany), and American Jennifer Doudna of the University of California (Berkeley, CA, USA) ???for the development of a method for genome ...
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