Results 121 to 130 of about 207,049 (372)

EspB and HtpG interact with the type III-A CRISPR/Cas system of Mycobacterium tuberculosis

Frontiers in Molecular Biosciences, 2023
Introduction:Mycobacterium tuberculosis (MTB) has a type III-A clustered regularly interspaced short palindromic repeat/CRISPR-associated protein (CRISPR/Cas) system consisting of a Csm1-5 and CRISPR RNA (crRNA) complex involved in the defense against ...
Mingmin Shi, Mingmin Shi, Hongtai Zhang, Joy Fleming, Wenjing Wei, Hong Chen, Xiaowei Dai, Yi Liu, Chuanyou Li, Fanlei Ran, Zhilong Wu, Yaguo Wang, Xilin Zhang, Huizhi Zhang, Lijun Bi, Lijun Bi   +15 more
doaj   +1 more source

Tailoring in fungi for next generation cellulase production with special reference to CRISPR/CAS system [PDF]

, 2021
Subhadeep Mondal, Suman Kumar Halder, Keshab Chandra Mondal   +2 more
openalex   +1 more source

In vitro reconstitution of Cascade-mediated CRISPR immunity in Streptococcus thermophilus [PDF]

, 2013
Clustered regularly interspaced short palindromic repeats (CRISPR)-encoded immunity in Type I systems relies on the Cascade (CRISPR-associated complex for antiviral defence) ribonucleoprotein complex, which triggers foreign DNA degradation by an ...
Giedrius Gasiunas, Ishino Y, Mark J Dickman, Mulepati S, Philippe Horvath, Rodolphe Barrangou, Sakharam P Waghmare, Tomas Sinkunas, Virginijus Siksnys   +8 more
core   +2 more sources

CRISPR-Cas Systems Reduced to a Minimum [PDF]

Molecular Cell, 2019
In two recent studies in Molecular Cell, Wright et al. (2019) report complete spacer integration by a Cas1 mini-integrase and Edraki et al. (2019) describe accurate genome editing by a small Cas9 ortholog with less stringent PAM requirements.
Almendros, Cristóbal, Kieper, Sebastian N., Brouns, Stan J.J.   +2 more
openaire   +3 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Regulation of Clostridiodes difficile CRISPR-Cas system by biofilm-associated factors and glucose

Инфекция и иммунитет
Clostridioides difficile is a spore-forming enteropathogenic anaerobic bacterium and one of the most common opportunistic human pathogens. Its pathogenicity relies on the production of toxins, sporulation, biofilm formation, and the ability to withstand ...
Anna S. Maikova, D. E. Polev, M. A. Khodorkovskii   +2 more
doaj   +1 more source

Live cell imaging of low- and non-repetitive chromosome loci using CRISPR-Cas9. [PDF]

, 2017
Imaging chromatin dynamics is crucial to understand genome organization and its role in transcriptional regulation. Recently, the RNA-guidable feature of CRISPR-Cas9 has been utilized for imaging of chromatin within live cells. However, these methods are
Adli, Mazhar, Bandaria, Jigar, Darzacq, Xavier, Kuscu, Cem, Mir, Mustafa, Parlak, Mahmut, Qin, Peiwu, Singh, Ritambhara, Szlachta, Karol, Yildiz, Ahmet   +9 more
core   +1 more source

Application of CRISPR Cas Systems for Biosensing

Biosensors, 2023
The essential properties of a biosensor are its sensitivity and selectivity to detect, monitor and quantify the biomarker(s) for the interests of medicine [...]
Chung Chiun Liu, Yifan Dai
openaire   +3 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Diversity and dynamics of the CRISPR-Cas systems associated with Bacteroides fragilis in human population [PDF]

, 2021
Tony J. Lam, Kate Mortensen, Yuzhen Ye
openalex   +1 more source