Results 251 to 260 of about 207,049 (372)

RNA-Targeting CRISPR–Cas Systems and Their Applications [PDF]

, 2020
Michał Burmistrz, Kamil Krakowski, Agata Krawczyk-Balska   +2 more
openalex   +1 more source

Palmitoylation‐Mediated Ubiquitination of SRPK1 Regulates Ferroptosis in High‐Fat‐Induced Erectile Dysfunction

Advanced Science, EarlyView.
Elevated exogenous palmitic acid promotes the S‐palmitoylation of SRPK1 in endothelial cells, a dynamic process governed by ZDHHC24 and APT1. This post‐translational modification strengthens the interaction between SRPK1 and the E3 ubiquitin ligase MIB1, thereby facilitating the proteasomal degradation of SRPK1.
Xiao‐Hui Tan, Ke‐Fan Li, Yi‐Ming Yuan, Man‐Cheng Xia, Fang‐Zhou Zhao, Hong‐Gang Ying, Zhuo Zhou, Peng‐Chao Gao, Guo‐Qing Xie, Xue‐Song Li, Hui Jiang, Rui‐Li Guan   +11 more
wiley   +1 more source

Exonuclease-fused CRISPR-cas system enhances targeted genome editing for functional genomics in soybean. [PDF]

BMC Plant Biol
Devkar V, Ghose K, D'Agostino L, Patil GB.   +3 more
europepmc   +1 more source

Unravelling the structural and mechanistic basis of CRISPR–Cas systems

, 2014
John van der Oost, Edze R. Westra, Ryan N. Jackson, Blake Wiedenheft   +3 more
openalex   +2 more sources

Characterization of CRISPR‐Cas systems in the Ralstonia solanacearum species complex [PDF]

, 2018
André da Silva Xavier, Juliana Cristina Fraleon de Almeida, Alessandra Gonçalves de Melo, Geneviève M. Rousseau, Denise M. Tremblay, Rafael Reis de Rezende, Sylvain Moineau, Poliane Alfenas‐Zerbini   +7 more
openalex   +1 more source

Quantitative Proteomics and CRISPR/Cas9 Editing Reveal UPR‐Mediated Control of Immunoglobulin Homeostasis in Hybridomas

Advanced Science, EarlyView.
BCR sequencing and subclone analysis correlated immunoglobulin (Ig) chain loss in dysfunctional hybridomas with disrupted monoclonal antibody homeostasis. Proteomics‐guided CRISPR/Cas9 editing revealed that the unfolded protein response (UPR) regulates aberrant Ig synthesis.
Rubing Zou, Xinying Lu, Ying Liu, Peiyu Yang, Shuo Sun, Yihua Liu, Yinyuan Mo, Guonian Zhu, Jae Seong Lee, Yirong Guo   +9 more
wiley   +1 more source

Teach plants to fish based on CRISPR-Cas system self-evolution. [PDF]

Plant Biotechnol J
Ma X, Miao L, Liu X.
europepmc   +1 more source

Comparative analysis of CRISPR-Cas systems of <em>Yersinia pestis</em> and <em>Escherichia coli</em> strains [PDF]

, 2017
Uchenna N. Eze, Ifekthar Bin Naser, Olunuga Omotola, Ubenyi Stanley Mary, Ugwu Chukwuebuka   +4 more
openalex   +1 more source

PDIA3 Inhibition Facilitates Sensitivity of IKE‐Induced Ferroptosis via STAT3/LCN2 Axis to Improve Glioblastoma Therapy

Advanced Science, EarlyView.
In this manuscript, protein disulfide isomerase A3 (PDIA3) is identified as a key factor mediating the susceptibility of ferroptosis in GBM. Inhibition of PDIA3 enhances IKE or cystine starvation‐induced ferroptosis in GBM cells by resulting in the accumulation of lipid peroxidation and a reduction in GSH level.
Jie Zhang, Wei Wang, Xin Liu, Peifen Lu, Xinjing Liu, Qiucheng Nie, Siyuan Xin, Hong Li, Donglin Yu, Xinyue Zhang, Kailong Li, Xiaomin Han, Shuping Zhang, Wei Chong, Lili Sun, Wei Li, Tao Xin, Jin Jiao, Qiang Ma, Yiju Wei   +19 more
wiley   +1 more source

Oxidative stress elicited by phage infection induces Staphylococcal type III-A CRISPR-Cas system. [PDF]

Nucleic Acids Res
Li Y, Zhao C, Cao Y, Chen X, Tang Y, Zhou X, Ingmer H, Jiao X, Li Q.   +8 more
europepmc   +1 more source