Results 111 to 120 of about 38,793 (285)

CRISPR/Cas Technology for the Diagnosis of Animal Infectious Diseases

Microorganisms
Increasingly complex epidemics of animal infectious diseases have emerged as a major risk to livestock production and human health. However, current detection methods for animal infectious diseases suffer from shortcomings such as insufficient ...
Shuling Meng, Zhi Zhao, Liju Huang, Xiaoyu Peng, Hailan Chen, Xiaochuan Tang   +5 more
doaj   +1 more source

Strawberry Notch 1 Acts as a Transcriptional Regulator Driving Oncogenic Programs in Liver Carcinogenesis

Advanced Science, EarlyView.
This study reports that SBNO1 protein is upregulated in several cancer entities. SBNO1 protein interacts with the basal transcription factor TFIID via TAF4, enabling its recruitment to transcription start sites and the modulation of target gene expression.
Sarah Fritzsche, Raisatun Nisa Sugiyanto, Kira Gür, Alina Krumme, Maxime Le Marois, Angelika Fraas, Aslihan Inal, Mario Huerta, Vanessa Henriques, Eva Eiteneuer, Thomas Albrecht, Alphonse Charbel, Michael T. Dill, Carsten Sticht, Carolina De La Torre, Stefan Pusch, Arianeb Mehrabi, Kai Breuhahn, Junfang Ji, Peter Schirmacher, Benjamin Goeppert, Stephanie Roessler   +21 more
wiley   +1 more source

Epstein‐Barr Virus Expressed Long Non‐Coding RNA (lncBARTs) Regulate EBV Latent Genome Replication

Advanced Science, EarlyView.
EBV produces abundant level of lncBARTs, which are essential for maintaining viral genome replication in EBV‐associated cancers. LncBARTs interact with a complex comprising BRD4, CTCF and viral protein EBNA1 at EBV oriP region. This interaction tethers oriP to host chromosomes, facilitating EBV episome replication.
Jiayan Liu, Dittman Lai‐Shun Chung, Larry Ka‐Yue Chow, Shuo Han, Wenkai Yi, Conor J. Cremin, Yingyin Liao, Pui Wang, Bobo Wing‐Yee Mok, Mingfang Ji, Jian Yan, Wei Dai, Honglin Chen   +12 more
wiley   +1 more source

Efficient engineering of a bacteriophage genome using the type I-E CRISPR-Cas system [PDF]

, 2014
Ruth Kiro, Dror Shitrit, Udi Qimron
openalex   +1 more source

Review on Anti-Biofilm Potential of CRISPR-Cas System on Various Pathogens

, 2023
Tamalika Chakraborty, Sumana Chatterjee, Lopamudra Datta, Ranjana Shaw   +3 more
openalex   +1 more source

A bioinformatic approach to identify confirmed and probable CRISPR–Cas systems in the Acinetobacter calcoaceticus–Acinetobacter baumannii complex genomes

Frontiers in Microbiology
IntroductionThe Acinetobacter calcoaceticus–Acinetobacter baumannii complex, or Acb complex, consists of six species: Acinetobacter baumannii, Acinetobacter calcoaceticus, Acinetobacter nosocomialis, Acinetobacter pittii, Acinetobacter seifertii, and ...
Jetsi Mancilla-Rojano, Jetsi Mancilla-Rojano, Víctor Flores, Miguel A. Cevallos, Sara A. Ochoa, Julio Parra-Flores, José Arellano-Galindo, Juan Xicohtencatl-Cortes, Ariadnna Cruz-Córdova, Ariadnna Cruz-Córdova   +9 more
doaj   +1 more source

CRISPR-Cas System in Aeromonas

Clustered, regularly interspaced short palindromic repeats (CRISPR) and the Cas-associated proteins (Cas) system (CRISPR-Cas) have been studied as a bacterial immune system that functions by preventing the entry of mobile genetic elements via nucleases.
Roger Orlando Medina-de la Cruz, Luis Uriel Gonzalez-Avila, Andres Saldaña-Padilla, Juan Manuel Bello-López, Cecilia Hernández-Cortez, Graciela Castro-Escarpulli   +5 more
openaire   +1 more source

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

Neural Circuits between Nodose Ganglion and Pulmonary Neuroendocrine Cells Regulate Lung Inflammatory Responses

Advanced Science, EarlyView.
TRPA1+αCGRP+ sensory neurons in the nodose ganglion detect external insults such as lipopolysaccharide (LPS) and interact directly with pulmonary neuroendocrine cells (PNECs), promoting their activation and proliferation. This neural‐epithelial interaction amplifies lung inflammation.
Jie Chen, Shitao Xie, Zhekai Lin, Caiqi Zhao, Rujia Tao, Yingying Ma, Xiaoyan Chen, Renlan Wu, Qingjian Han, Pengfei Sui, Sheng Wang, Hongbin Ji, Hai Song, Xiaoming Zhang, Yangang Sun, Yuanlin Song, Xiao Su   +16 more
wiley   +1 more source

Structure Basis for Directional R-loop Formation and Substrate Handover Mechanisms in Type I CRISPR-Cas System [PDF]

, 2017
Yibei Xiao, Min Luo, Robert P. Hayes, Jonathan Kim, Sherwin Ng, Fang Ding, Maofu Liao, Ailong Ke   +7 more
openalex   +1 more source