Results 111 to 120 of about 717,978 (310)
Журнал инфектологии, 2019 The aim of this research was to analyze and compare CRIPSR loci and cas-proteins of Yersinia pseudotuberculosis strains isolated in different territories from patients with various clinical manifestations of pseudotuberculosis.Materials and Methods ...
N. P. Peretolchina +7 more
doaj +1 more source
Fractional Multidimensional System [PDF]
arXiv, 2017 The multidimensional ($n$-D) systems described by Roesser model are presented in this paper. These $n$-D systems consist of discrete systems and continuous fractional order systems with fractional order $\nu$, $0<\nu<1$. The stability and Robust stability of such $n$-D systems are investigated.
arxiv
HNF3α Targets Nckap1l and Promotes Renal Fibrosis Following Ischemia‐Reperfusion Injury
Advanced Science, EarlyView.Hepatocyte Nuclear Factor 3 alpha (HNF3α) is significantly upregulated in renal tubular epithelial cells of CKD patients and fibrotic mice. Deletion of HNF3α mitigates IRI‐induced renal fibrosis, while overexpression worsens it. HNF3α directly regulates NCK‐associated protein 1‐like (Nckap1l), whose overexpression exacerbates fibrosis.
Ling Hou +7 more
wiley +1 more source
Delivery of A Chemically Modified Noncoding RNA Domain Improves Dystrophic Myotube Function
Advanced Science, EarlyView.CYTOR is a pro‐myogenic ncRNA in skeletal muscle. Here, chemical probing of CYTOR, coupled with functional cellular assays identifies exon 2 as an independent myogenic RNA domain. Chemical engineering of CYTOR exon 2 RNA improves pharmacologic properties, including RNA stability and cell‐autonomous immunogenicity.
Zeinabou Niasse‐Sy +6 more
wiley +1 more source
Exploiting CRISPR-Cas to manipulate Enterococcus faecalis populations
eLife, 2017 CRISPR-Cas provides a barrier to horizontal gene transfer in prokaryotes. It was previously observed that functional CRISPR-Cas systems are absent from multidrug-resistant (MDR) Enterococcus faecalis, which only possess an orphan CRISPR locus, termed ...
Karthik Hullahalli +2 more
doaj +1 more source
NF2 is Essential for Human Endoderm Development
Advanced Science, EarlyView.This study demonstrates that NF2, moesin‐ezrin‐radixin like (MERLIN) tumor suppressor (NF2) is essential for human endoderm formation. NF2 knockout human induced pluripotent stem cells fail to form endoderm both in vitro and in vivo due to yes‐associated protein 1 (YAP1) nuclear translocation, redirecting differentiation toward myofibroblast‐like cells.
Minjin Jeong +5 more
wiley +1 more source
arXiv, 2006 The paper deals with combinatorial and stochastic structures of cubical token systems. A cubical token system is an instance of a token system, which in turn is an instance of a transition system. It is shown that some basic results of combinatorial and stochastic parts of media theory hold almost in identical form for cubical token systems, although ...
arxiv
Advanced Science, EarlyView.Comprehensive epigenomic and transcriptomic profiling revealed a dynamic enhancer landscape and gene expression program associated with nephrolithiasis, highlighting RXRα as a central transcription factor in this regulatory network. Tubular‐specific deletion of RXRα increased intrarenal CaOx crystal deposition, while its activation with Bexarotene ...
Yu Yang +12 more
wiley +1 more source
CRISPR/Cas-based nucleic acid detection strategies: Trends and challenges
HeliyonCRISPR/Cas systems have become integral parts of nucleic acid detection apparatus and biosensors. Various CRISPR/Cas systems such as CRISPR/Cas9, CRISPR/Cas12, CRISPR/Cas13, CRISPR/Cas14 and CRISPR/Cas3 utilize different mechanisms to detect or ...
Jian Zhou +3 more
doaj
Separable bi-Hamiltonian systems with quadratic in momenta first integrals [PDF]
arXiv, 2003 Geometric separability theory of Gel'fand-Zakharevich bi-Hamiltonian systems on Riemannian manifolds is reviewed and developed. Particular attention is paid to the separability of systems generated by the so-called special conformal Killing tensors, i.e. Benenti systems.
arxiv