Results 121 to 130 of about 717,978 (310)

P21‐Activated Kinase 2 as a Novel Target for Ventricular Tachyarrhythmias Associated with Cardiac Adrenergic Stress and Hypertrophy

open access: yesAdvanced Science, EarlyView.
Ca2+/calmodulin‐dependent kinase II (CaMKII) activation is likely driven by oxidative stress, particularly excessive reactive oxygen species (ROS) production. This study identifies P21‐activated kinase 2 (Pak2) as a novel regulator of ROS‐induced CaMKII activation and abnormal Ca2⁺ dynamics in acute adrenergic and chronic pressure‐overload stressed ...
Tao Li   +21 more
wiley   +1 more source

Demonstrating the Use of a Fungal Synthesized Quinone in a Redox Flow Battery

open access: yesBatteries &Supercaps, Volume 6, Issue 1, January 2023., 2023
Biobased: The filamentous fungus can be used as an environmentally and sustainable benign source to produce the bio‐based quinone phoenicin. This natural compound shows electrochemical properties, which can be used as the active material in the negative electrolyte in a redox flow battery with results showing that biologically produced quinones may ...
Charlotte Overgaard Wilhelmsen   +15 more
wiley   +1 more source

A Step towards an Easy Interconversion of Various Number Systems [PDF]

open access: yesarXiv, 2011
Any system that is used for naming or representing numbers is a number system, also known as numeral system. The modern civilization is familiar with decimal number system using ten digits. However digital devices and computers use binary number system instead of decimal number system, using only two digits namely, 0 and 1 based on the fundamental ...
arxiv  

Microneedles at the Forefront of Next Generation Theranostics

open access: yesAdvanced Science, EarlyView.
The TOC figure illustrates the revolutionary role of microneedles in modern medicine, showcasing their dual diagnostic and therapeutic functions. On the left, microneedles access interstitial fluid for real‐time monitoring of biomarkers like glucose and hormones.
Chan Wang   +8 more
wiley   +1 more source

Molecular memory of prior infections activates the CRISPR/Cas adaptive bacterial immunity system [PDF]

open access: hybrid, 2012
Kirill A. Datsenko   +5 more
openalex   +1 more source

YC‐4‐3, a Novel Glycogen Synthase Kinase 3β Inhibitor, Alleviates the Endoplasmic Reticulum Stress of Macrophages in Primary Immune Thrombocytopenia

open access: yesAdvanced Science, EarlyView.
A patented GSK‐3β inhibitor (GSK‐3βi), new benzothiazepinone compounds (BTZs), YC‐4‐3, can modulate the inflammatory status of macrophages in primary immune thrombocytopenia (ITP), and improve the thrombocytopenia in murine ITP models by directly interacting with endoplasmic reticulum (ER) stress response.
Pengcheng Xu   +10 more
wiley   +1 more source

Nonlinear Modal Decoupling of Multi-Oscillator Systems with Applications to Power Systems [PDF]

open access: yesarXiv, 2016
Many natural and manmade dynamical systems that are modeled as large nonlinear multi-oscillator systems like power systems are hard to analyze. For such a system, we propose a nonlinear modal decoupling (NMD) approach inversely constructing as many decoupled nonlinear oscillators as the system oscillation modes so that individual decoupled oscillators ...
arxiv  

The CRISPR-Cas system

open access: yes, 2020
Derived from and inspired by the adaptive immune system of bacteria, CRISPR has gone from basic biology knowledge to a revolutionizing biotechnological tool, applicable in many research areas such as medicine, industry and agriculture. The full mechanism of CRISPR-Cas9 was first published in 2012 and various CRISPR-Cas systems have already passed the ...
Stens, Cassandra   +2 more
openaire   +1 more source

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