Results 61 to 70 of about 869,266 (345)

Type I-F CRISPR-Cas resistance against virulent phages results in abortive infection and provides population-level immunity [PDF]

, 2020
This is the final version. Available from the publisher via the DOI in this record.Type I CRISPR-Cas systems are abundant and widespread adaptive immune systems in bacteria and can greatly enhance bacterial survival in the face of phage infection.
Fineran, PC, Salmond, GPC, Staals, RHJ, Vercoe, RB, Watson, BNJ, Westra, ER   +5 more
core   +1 more source

CRISPR-Cas systems are widespread accessory elements across bacterial and archaeal plasmids

bioRxiv, 2021
Many prokaryotes encode CRISPR-Cas systems as immune protection against mobile genetic elements (MGEs), yet, a number of MGEs also harbor CRISPR-Cas components.
R. Pinilla-Redondo, Jakob Russel, David Mayo-Muñoz, Shiraz A. Shah, R. Garrett, J. Nesme, J. Madsen, Peter C. Fineran, S. Sørensen   +8 more
semanticscholar   +1 more source

Anti-CRISPRs: Protein Inhibitors of CRISPR-Cas Systems.

Annual Review of Biochemistry, 2020
Clustered regularly interspaced short palindromic repeats (CRISPR) together with their accompanying cas (CRISPR-associated) genes are found frequently in bacteria and archaea, serving to defend against invading foreign DNA, such as viral genomes.
A. Davidson, Wang Lu, S. Stanley, Jingrui Wang, M. Mejdani, Chantel N Trost, Brian T Hicks, Jooyoung Lee, E. Sontheimer   +8 more
semanticscholar   +1 more source

CRISPR-Cas-Based Engineering of Probiotics

BioDesign Research, 2023
Probiotics are the treasure of the microbiology fields. They have been widely used in the food industry, clinical treatment, and other fields. The equivocal health-promoting effects and the unknown action mechanism were the largest obstacles for further ...
Ling Liu, Shimaa Elsayed Helal, Nan Peng
doaj   +1 more source

Bacteriophage DNA glucosylation impairs target DNA binding by type I and II but not by type V CRISPR-Cas effector complexes [PDF]

, 2017
Prokaryotes encode various host defense systems that provide protection against mobile genetic elements. Restriction-modification (R-M) and CRISPR-Cas systems mediate host defense by sequence specific targeting of invasive DNA.
Anders, C., Brouns, S.J.J., Dickman, M.J., Houkes, J., Jinek, M., Kunne, T., Lochs, S.J.A., Mohanraju, P., Swarts, D.C., van der Oost, J., Vlot, M., Zheng, P.   +11 more
core   +3 more sources

Prevalence of CRISPR-Cas Systems and Their Possible Association with Antibiotic Resistance in Enterococcus faecalis and Enterococcus faecium Collected from Hospital Wastewater

Infection and Drug Resistance, 2022
Purpose This study aimed to evaluate the presence of CRISPR-Cas system genes and their possible association with antibiotic resistance patterns of Enterococcus faecalis and Enterococcus faecium species isolated from hospital wastewater (HWW) samples of ...
Athraa Harjan Mohsen Alduhaidhawi, S. AlHuchaimi, Thikra Abdullah Al-Mayah, M. T. Al-Ouqaili, S. S. Alkafaas, S. Muthupandian, M. Saki   +6 more
semanticscholar   +1 more source

COMPARATIVE ANALYSIS OF CRISPR-CAS SYSTEM STRUCTURES OF YERSINIA PSEUDOTUBERCULOSIS IP32953 AND IP31758

Acta Biomedica Scientifica, 2018
Background. Pseudotuberculosis is still relevant problem in medical science and public health of Russia and other countries. Typing of Y. рseudotuberculosis strains by their CRISPR systems is a perspective tool for monitoring of Yersinia populations as ...
N. P. Peretolchina, A. Y. Borisenko, Yu. P. Dzhioev, V. I. Zlobin   +3 more
doaj   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

Phylogenetic Distribution of CRISPR-Cas Systems in Antibiotic-Resistant Pseudomonas aeruginosa

mBio, 2015
Pseudomonas aeruginosa is an antibiotic-refractory pathogen with a large genome and extensive genotypic diversity. Historically, P. aeruginosa has been a major model system for understanding the molecular mechanisms underlying type I clustered regularly ...
Alex van Belkum, Leah B. Soriaga, Matthew C. LaFave, Srividya Akella, Jean-Baptiste Veyrieras, E. Magda Barbu, Dee Shortridge, Bernadette Blanc, Gregory Hannum, Gilles Zambardi, Kristofer Miller, Mark C. Enright, Nathalie Mugnier, Daniel Brami, Stéphane Schicklin, Martina Felderman, Ariel S. Schwartz, Toby H. Richardson, Todd C. Peterson, Bolyn Hubby, Kyle C. Cady   +20 more
doaj   +1 more source

PAM-repeat associations and spacer selection preferences in single and co-occurring CRISPR-Cas systems

Genome Biology, 2021
Background The adaptive CRISPR-Cas immune system stores sequences from past invaders as spacers in CRISPR arrays and thereby provides direct evidence that links invaders to hosts.
Jochem N. A. Vink, Jan H. L. Baijens, Stan J. J. Brouns   +2 more
doaj   +1 more source