Results 81 to 90 of about 717,978 (310)
CRISPR-Cas: an adaptive immunity system in prokaryotes [PDF]
F1000 Biology Reports, 2009 Most of the archaea and numerous bacteria possess an elaborate system of adaptive immunity to mobile genetic elements known as the CRISPR (clustered regularly interspaced short palindromic repeats)-associated system (CRISPR-Cas), which consists of arrays of short repeats interspersed with unique DNA spacers and adjacent operons encompassing CRISPR ...
Eugene V. Koonin, Kira S. Makarova
openaire +3 more sources
Advanced Functional Materials, EarlyView.Oct4‐nanoscript, a biomimetic nanoparticle‐based artificial transcription factor, precisely regulates cellular rejuvenation by activating Oct4 target genes, restoring epigenetic marks, and reducing DNA damage. In a progeria model, it effectively rescued aging‐associated pathologies and extended lifespan.
Hongwon Kim +8 more
wiley +1 more source
Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy
Advanced Healthcare Materials, EarlyView.The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq +4 more
wiley +1 more source
Compact integral manifolds of differential systems [PDF]
arXiv, 2010 The boundedness tests for the number of compact integral manifolds of autonomous ordinary differential systems, of autonomous total differential systems, of linear systems of partial differential equations, of Pfaff systems of equations, and of systems of exterior differential equations are proved.
arxiv
Using Structure-Behavior Coalescence Method for Systems Definition 2.0 [PDF]
arXiv, 2021 Systems definition is an artifact created by humans to describe what a system is. A system has been defined, by systems definition 1.0, hopefully to be an integrated whole, embodied in its components, their interrelationships with each other and the environment, and the principles and guidelines governing its design and evolution.
arxiv
Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting
Advanced Materials, EarlyView.CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu +4 more
wiley +1 more source
Morphisms of Networks of Hybrid Open Systems [PDF]
arXiv, 2019 This thesis (defended 10/07/2019) develops a theory of networks of hybrid open systems and morphisms. It builds upon a framework of networks of continuous-time open systems as product and interconnection. We work out categorical notions for hybrid systems, deterministic hybrid systems, hybrid open systems, networks of hybrid open systems, and morphisms
arxiv
Contraction analysis of time-varying DAE systems via auxiliary ODE systems [PDF]
arXiv, 2023 This paper studies the contraction property of time-varying differential-algebraic equation (DAE) systems by embedding them to higher-dimension ordinary differential equation (ODE) systems. The first result pertains to the equivalence of the contraction of a DAE system and the uniform global exponential stability (UGES) of its variational DAE system ...
arxiv
Micro‐ and Nano‐Bots for Infection Control
Advanced Materials, EarlyView.This review presents a strategic vision for integrating micro‐ and nanobots in the pipeline for infection diagnosis, prevention, and treatment. To develop these robots as a practical solution for infection management, their design principles are clarified based on their propulsion mechanisms and then categorized infection management domains based on ...
Azin Rashidy Ahmady +5 more
wiley +1 more source
First integrals of ordinary linear differential systems [PDF]
arXiv, 2012 The spectral method for building first integrals of ordinary linear differential systems is elaborated. Using this method, we obtain bases of first integrals for linear differential systems with constant coefficients, for linear nonautonomous differential systems integrable in closed form (algebraic reducible systems, triangular systems, the Lappo ...
arxiv