Results 181 to 190 of about 321,595 (358)

Advancements in CRISPR-based therapies for ocular pathologies: from disease mechanisms to intervention strategies. [PDF]

Theranostics
Li Q, Bao Q, Zhao S, Wu F, Li Y, Wang K, Li W, Gao H.   +7 more
europepmc   +1 more source

Evolution of CRISPR technology and its implications in oral cancer diagnosis

P. Anitha, Paramasivam Arumugam, Vijayashree Priyadharsini Jayaseelan   +2 more
openalex   +1 more source

TRIM56 Aggravates Cerebral Ischemia‐Reperfusion Injury via Inhibiting KLF4‐Activated Ferroptosis Signaling

Advanced Science, EarlyView.
This study reveals that the E3 ubiquitin ligase TRIM56 exacerbates neuronal ferroptosis and brain damage by mediating K48‐linked ubiquitination and degradation of KLF4, leading to suppression of the xCT/GSH/GPX4 axis. Targeting TRIM56 alleviates cerebral ischemia‐reperfusion injury in vivo and in vitro, highlighting its therapeutic potential.
Qiangping Wang, Shuang Li, Man Li, Wenke Zhou, Jianqing Zhang, Zhenfu Wu, Zhaoqi Mao, Juan Wan, Xinhao Tang, Baoping Zheng, Qiang Liu, Zhendong Li, Xiaobing Jiang, Qingping Wu, Youfan Ye, Haijun Wang   +15 more
wiley   +1 more source

CRISPR-Cas targeting in <i>Haloferax volcanii</i> promotes within-species gene exchange by triggering homologous recombination. [PDF]

Microlife
Choudhary DK, Turgeman-Grott I, Robinzon S, Gophna U.   +3 more
europepmc   +1 more source

Peptide dendrimers transfecting CRISPR/Cas9 plasmid DNA: optimization and mechanism

Susanna Zamolo, Elena Zakharova, Lise Boursinhac, Florian Hollfelder, Tamis Darbre, Jean‐Louis Reymond   +5 more
openalex   +2 more sources

TBK1 Induces the Formation of Optineurin Filaments That Condensate with Polyubiquitin and LC3 for Cargo Sequestration

Advanced Science, EarlyView.
Phosphorylation of Optineurin by TBK1 induces the formation of filaments that condensate upon binding to linear polyubiquitin. Membrane‐anchored LC3 partitions into these condensates, suggesting that phase separation of filamentous Optineurin with ubiquitylated cargo promotes the sequestration of cargo and its subsequent alignment with LC3‐positive ...
Maria G. Herrera, Lena Kühn, Lisa Jungbluth, Verian Bader, Laura J. Krause, David Kartte, Elias Adriaenssens, Sascha Martens, Jörg Tatzelt, Carsten Sachse, Konstanze F. Winklhofer   +10 more
wiley   +1 more source

Activated PI3K delta syndrome 1 mutations cause neutrophilia in zebrafish larvae

Disease Models & Mechanisms, 2023
Stone Elworthy, Holly A. Rutherford, Tomasz K. Prajsnar, Noémie M. Hamilton, Katja Vogt, Stephen A. Renshaw, Alison M. Condliffe   +6 more
doaj   +1 more source

nf-core/crisprseq: a versatile pipeline for comprehensive analysis of CRISPR gene editing and screening assays. [PDF]

NAR Genom Bioinform
Mir-Pedrol J, Kuhlburger L, Sanvicente-García M, Yazar M, Ryan CJ, Krakau S, Gabernet G, Güell M, Bonfanti M, Nf-Core Community, Nahnsen S.   +10 more
europepmc   +1 more source

High-content CRISPR screening

Nature Reviews Methods Primers, 2022
C. Bock, Paul Datlinger, Florence M. Chardon, M. A. Coelho, Matthew B Dong, K. Lawson, Tian Lu, Laetitia Maroc, Thomas M. Norman, Bicna Song, G. Stanley, Sidi Chen, M. Garnett, Wei Li, J. Moffat, Lei S. Qi, Rebecca S. Shapiro, J. Shendure, J. Weissman, X. Zhuang   +19 more
semanticscholar   +1 more source

Comprehensive Profiling of N6‐methyladnosine (m6A) Readouts Reveals Novel m6A Readers That Regulate Human Embryonic Stem Cell Differentiation

Advanced Science, EarlyView.
This research deciphers the m6A transcriptome by profiling its sites and functional readout effects: from mRNA stability, translation to alternative splicing, across five different cell types. Machine learning model identifies novel m6A‐binding proteins DDX6 and FXR2 and novel m6A reader proteins FUBP3 and L1TD1.
Zhou Huang, Rucong Liu, Zibaguli Wubulikasimu, Wanqing Zhao, Jiaqi Huang, Jiaxuan Wang, Tianyuan Zhang, Rui Fan, Wei Kong, Qinghua Cui, Yang Li, Yuan Zhou   +11 more
wiley   +1 more source