Results 91 to 100 of about 10,210,911 (299)

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Spatiotemporal variations of vegetation and its determinants in the National Key Ecological Function Area on Loess Plateau between 2000 and 2015

Ecology and Evolution, 2019
China defined 25 National Key Ecological Function Areas in 2010 and adopted various measures to support ecosystem restoration in these areas. During the process of environment policymaking, it is important to observe the variation of vegetation and its ...
Haiguang Hao, Yuanyuan Li, Huiyuan Zhang, Ruixue Zhai, Haiyan Liu   +4 more
doaj   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Diagnostic criteria [PDF]

Diabetologia, 1983
R. J. Jarrett, K. G. M. M. Alberti
openaire   +2 more sources

Flying qualities criteria for superaugmented aircraft [PDF]

, 1984
An overview of Dryden superaugmented aircraft flying qualities research is presented. This includes F-8 digital fly by wire flight experiments, orbiter flying qualities, shuttle improvements, AFTI/F-16, flying qualities and control system alternatives ...
Berry, D. T.
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

An integrated approach unveils novel mechanisms of nicotine-induced neurotoxicity in zebrafish larvae

Environmental Chemistry and Ecotoxicology
Nicotine is a ubiquitous environmental pollutant which may exert neurotoxicity to aquatic organisms. However, the mechanisms at environmentally relevant concentrations remain inadequately understood.
Yu Kou, Changsheng Guo, Yan Zhang, Yanghui Deng, Xingxing Yin, Jian Xu   +5 more
doaj   +1 more source

On Urabe's criteria of isochronicity

, 2000
We give a short proof of Urabe's criteria for the isochronicity of periodical solutions of the equation $\ddot{x}+g(x)=0$. We show that apart from the harmonic oscillator there exists a large family of isochronous potentials which must all be non ...
Chicone C, Keller J B, Keller J B, Landau L, Landau L D, Landau L D, Marko Robnik, Urabe M, Urabe M, Valery G Romanovski   +9 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source