Results 81 to 90 of about 3,179,369 (392)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

ALTERNATIVE TERMINATION CRITERION FOR K-SPECIFIED CRISP DATA CLUSTERING ALGORITHMS

Informatyka, Automatyka, Pomiary w Gospodarce i Ochronie Środowiska, 2017
In this paper the analysis of k-specified (namely k-means) crisp data partitioning pre-clustering algorithm’s termination criterion performance is described. The results have been analyzed using the clustering validity indices.
Volodymyr Mosorov, Taras Panskyi, Sebastian Biedron   +2 more
doaj   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

The psychometric properties of GHQ for detecting common mental disorder among community dwelling men in Goa, India. [PDF]

, 2017
BACKGROUND: There have not been many attempts to validate screening measures for common mental disorders (CMD) in low- and middle-income countries. The aim of this study was to examine the criterion validity of the General Health Questionnaire 12 (GHQ-12)
Endsley, Paige, Nadkarni, Abhijit, Weobong, Benedict   +2 more
core   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Appropriateness Fit and Criterion-Related Validity [PDF]

Applied Psychological Measurement, 1993
Unmotivated or suspicious test takers in con current validation studies can cause numerous problems for test users. The effects of these problems, however, have not been carefully examined. This study used item response theory-based appro priateness fit indexes to identify and remove from a validation sample those examinees whose response patterns did
Schmitt, Neal, Cortina, José M., Whitney, David J.   +2 more
openaire   +2 more sources

The German Communities That Care Youth Survey: dimensionality and validity of risk factors

Frontiers in Public Health
BackgroundCommunities That Care (CTC) is an evidence-based community change strategy for supporting healthy youth development. One of its key elements is the development of a community profile to identify and prioritise risk factors for health and ...
Maren Reder, Ronja A. Runge, Helge Schlüter, Renate Soellner   +3 more
doaj   +1 more source

Validation and standardization of two job- personality questionnaires, DISC Personality Profiler and Hogan Personality Inventory, among personnels of IRANs Refinery and Distribution of Petroleum Products Company [PDF]

پژوهش‌های علوم شناختی و رفتاری, 2019
Most of the present personality measurement instruments of the country are for judging about the people in clinical contexts and they are not so much applicable in organizational contexts.
Narjes Fasihizadeh, sayed hamid reza oreyzi samani, H Shahbazi   +2 more
doaj   +1 more source

Psychometric Evaluation of the Shared Care Instrument in a Sample of Home Health Care Family Dyads [PDF]

, 2005
Researchers have studied negative effects of caregiving on a family caregiver; however, less is known about positive aspects of exchanging assistance for both members of a family caregiving dyad.
Sebern, Margaret
core   +1 more source

Nonadditive conditional entropy and its significance for local realism

, 2000
Based on the form invariance of the structures given by Khinchin's axiomatic foundations of information theory and the pseudoadditivity of the Tsallis entropy indexed by q, the concept of conditional entropy is generalized to the case of nonadditive ...
A.K Rajagopal, Abe, Abe, Balian, Beck, Cerf, Cerf, Dickson, dos Santos, Horodecki, Horodecki, Horodecki, Khinchin, Peres, Popescu, Popescu, Sumiyoshi Abe, Tsallis, Tsallis, Werner   +19 more
core   +1 more source