Results 151 to 160 of about 1,687 (191)
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The Sites of Action of Allopurinol in Crithidia fasciculata*
The Journal of Protozoology, 1973SYNOPSISReversal of the growth inhibition of Crithidia fasciculata by allopurinol requires both a purine and a pyrimidine. Hypoxanthine is the most effective purine in the reversal. Cell‐free extracts were prepared which were capable of the decarboxylation of orotidine 5′‐phosphate.
V C, Dewey, G W, Kidder
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Desmosomes and hemidesmosomes in the flagellate Crithidia fasciculata
Zeitschrift f�r Zellforschung und Mikroskopische Anatomie, 1970The flagellum of the trypanosomatid flagellate Crithidia fasciculata expands asymmetrically as it emerges from the reservoir. Where the flagellar memhrane approaches the membrane lining the reservoir, desmosomes are found. These structures are arranged in several slightly curved lines and have many features in common with vertebrate desmosomes.
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The biosynthesis of trypanothione and N1-glutathionylspermidine in Crithidia fasciculata
Molecular and Biochemical Parasitology, 1986Studies on the biosynthesis of trypanothione [N1,N8-bis(glutathionyl)-spermidine] in the insect trypanosomatid Crithidia fasciculata have led to the discovery of an additional sulfur-containing peptide conjugated to spermidine. Labelling studies with [3H]spermidine show that 50% of the total intracellular spermidine is incorporated into peptide ...
A H, Fairlamb, G B, Henderson, A, Cerami
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Fatty Acid Oxidation in Crithidia fasciculata
Canadian Journal of Biochemistry, 1972Cultures of the kinetoplastid Crithidia fasciculata at their logarithmic phase of growth oxidize [1-14C]palmitate to α-hydroxy fatty acids, CO2, and water-soluble products. 2-Hydroxy[1-14C]stearate is also decarboxylated. The decarboxylation of [1-14C]palmitate by cells and homogenate decreases in the presence of nonradioactive L-2-hydroxypalmitate ...
C, Vakirtzi-Lemonias +2 more
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Development of a pharmacodynamic screening model with Crithidia fasciculata
Wiener klinische Wochenschrift, 2006The genus Crithidia is a member of the family Trypanosomatidae and is related to the genera Leishmania and Trypanosoma with which it shares a variety of biochemical mechanisms, such as polyamine synthesis and methionin salvage. In consequence, a screening system for antiparasitic candidate material has been developed with Crithidia fasciculata, a ...
Tasanor, Oumaporn +5 more
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Triphosphoinositide phosphodiesterase in a protozoan-crithidia. fasciculata
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1973Abstract The hydrolysis of triphosphoinositide by a phosphodiesterase has been demonrated in a species of Trypanosomidae ( Crithidia fasciculata ). The activity in the crude homogenate was stimulated by K + , and diethyl ether or cetyltrimethylammonium bromide. The pH optimum was 7.0–7.2. The enzyme specifically required Ca 2+ and was very sensitive
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Characterization of messenger RNA populations of Crithidia fasciculata
Archives of Biochemistry and Biophysics, 1981Abstract Cells of Crithidia fasciculata taken from exponentially growing cultures display a relatively high content of poly(A) RNA (roughly 45% of the total) in a nonpolysomal compartment. The proportion of this fraction is significantly higher than that of the free ribosomal units.
E, Rondinelli +3 more
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Crithidia fasciculata as Feeder Cells for Malaria Parasites
Experimental Parasitology, 1995Crithidia fasciculata was used to replace murine peritoneal wash cells as feeder cells for the adaptation of Plasmodium falciparum isolates to continuous culture in vitro, thus avoiding the need to sacrifice animals. Fourteen of 17 malaria parasite isolates in one study, and 12 of 12 isolates in a second study, were successfully adapted to continuous ...
F M, Awad-el-Kariem +3 more
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Anaerobic Metabolism of Crithidia fasciculata*
The Journal of Protozoology, 1961SYNOPSIS: Crithidia fasciculata was cultured in a modification of the nutrient medium described by Cowperthwaite in 1951. Carbon dioxide, lactic acid, succinic acid and ethyl alcohol were produced by the organisms during anaerobic conditions. Hexokinase, enolase, alcohol dehydrogenase and glucoses‐phosphate dehydrogenase were demonstrated in ho ...
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Respiratory control in mitochondria from crithidia fasciculata
Biochemical and Biophysical Research Communications, 1972Summary The trypanosomatid Crithidia fasciculata contains a single bifurcated mitochondrial organelle, and a method is described for its isolation as a relatively intact structure. These preparations carry out oxidative phosphorylation and show respiratory control with succinate as substrate.
J J, Toner, M M, Weber
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